Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pharmaceutical Poisoning: Treatment Strategies01:26

Pharmaceutical Poisoning: Treatment Strategies

Treatment strategies for poisoning are a critical aspect of emergency medicine, focusing on preventing the absorption of toxins and enhancing their elimination. When a poisoning incident occurs, the first response is to halt exposure and decontaminate the patient, particularly through gastrointestinal (GI) methods if the poison was ingested.Gastrointestinal Decontamination Techniques:Activated charcoal is the cornerstone of GI decontamination. It works through adsorption, binding the toxin to...
Pharmaceutical Poisoning: Potential Scenarios01:26

Pharmaceutical Poisoning: Potential Scenarios

Pharmaceutical poisoning can occur through various channels, impacting an estimated 2 million hospitalized patients in the U.S. annually with serious adverse drug responses. These scenarios encompass both therapeutic uses, such as drug toxicity, where even standard dosages can lead to severe central nervous system depression, and non-therapeutic exposures, including accidental ingestion by children, and environmental and occupational exposures.Unintentional poisonings often involve exploratory...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Preoperative Diagnostic Factors Associated With Early MCID Achievement in BCTQ Outcomes Following Carpal Tunnel Release.

Journal of hand surgery global online·2026
Same author

Associations Between Preoperative Diagnostic Tests and Surgical Recommendation for Carpal Tunnel Syndrome.

Journal of hand surgery global online·2026
Same author

Reported Minimal Clinically Important Differences for Patient-Reported Outcome Measures in Hand and Upper-Extremity Surgery: A Systematic Review.

Journal of hand surgery global online·2026
Same author

Localizing Nerve Injury, Defining Injury Severity, and Estimating Prognosis (Nerve SPACE 2025).

Journal of hand surgery global online·2026
Same author

Enhancing Carpal Tunnel Syndrome Diagnosis: The Combined Use of CTS-6 and Ultrasound Measured Median Nerve CSA.

Hand (New York, N.Y.)·2026
Same author

Primary care provider referral patterns and awareness of biologic therapy for uncontrolled asthma.

The journal of allergy and clinical immunology. Global·2026

Related Experiment Video

Updated: Jun 30, 2026

Source and Route of Pyrrolizidine Alkaloid Contamination in Tea Samples
06:04

Source and Route of Pyrrolizidine Alkaloid Contamination in Tea Samples

Published on: September 28, 2022

Syrian rue tea: a recipe for disaster.

Aslihan Yuruktumen1, Sevilay Karaduman, Fecri Bengi

  • 1Kent Hospital, Emergency Department, 8229 s no: 30 Cigli, Izmir 35580, Turkey. a.yuruktumen@deu.edu.tr

Clinical Toxicology (Philadelphia, Pa.)
|September 23, 2008
PubMed
Summary

High doses of Syrian rue (Peganum harmala) seeds can cause severe poisoning, leading to unconsciousness and organ dysfunction. However, supportive care typically results in recovery.

More Related Videos

Tea Aroma Analysis Based on Solvent-Assisted Flavor Evaporation Enrichment
04:36

Tea Aroma Analysis Based on Solvent-Assisted Flavor Evaporation Enrichment

Published on: May 26, 2023

Related Experiment Videos

Last Updated: Jun 30, 2026

Source and Route of Pyrrolizidine Alkaloid Contamination in Tea Samples
06:04

Source and Route of Pyrrolizidine Alkaloid Contamination in Tea Samples

Published on: September 28, 2022

Tea Aroma Analysis Based on Solvent-Assisted Flavor Evaporation Enrichment
04:36

Tea Aroma Analysis Based on Solvent-Assisted Flavor Evaporation Enrichment

Published on: May 26, 2023

Area of Science:

  • Toxicology
  • Pharmacology
  • Ethnobotany

Background:

  • Peganum harmala (Syrian rue) is a plant with a history of medicinal and psychoactive use.
  • Its seeds contain harmaline and harmine, known monoamine oxidase inhibitors.
  • While low doses induce stimulant and hallucinogenic effects in humans, high doses can be toxic.

Observation:

  • A case study involved a 41-year-old female who ingested approximately 100g of P. harmala seeds, a dose significantly exceeding recommended amounts.
  • The patient presented to the emergency department unconscious, with severe hypertension, tachycardia, and tachypnea.
  • Initial laboratory results indicated significant hepatic and renal function impairment.

Findings:

  • The patient's condition improved following intubation and intensive supportive care over five days.
  • Gradual normalization of consciousness, hepatic, and renal function markers was observed.
  • High-dose Peganum harmala ingestion can lead to life-threatening poisoning.

Implications:

  • This case highlights the potential dangers of consuming excessive amounts of P. harmala.
  • Prompt medical intervention and supportive therapy are crucial for managing severe Peganum harmala poisoning.
  • Understanding the dose-dependent effects of P. harmala is essential for both traditional use and clinical settings.