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Updated: Jun 30, 2026

Preparation of Tunable Extracellular Matrix Microenvironments to Evaluate Schwann Cell Phenotype Specification
Published on: June 2, 2020
Regulation of Schwann cell function by the extracellular matrix
Michael A Chernousov1, Wei-Ming Yu2, Zu-Lin Chen2
1Weis Center for Research, Geisinger Clinic, Danville, Pennsylvania.
Abstract:
Laminins and collagens are extracellular matrix proteins that play essential roles in peripheral nervous system development. Laminin signals regulate Schwann cell proliferation and survival as well as actin cytoskeleton dynamics, which are essential steps for radial sorting and myelination of peripheral axons by Schwann cells. Collagen and their receptors promote Schwann cell adhesion, spreading, and myelination as well as neurite outgrowth. In this article, we will review the recent advances in the studies of laminin and collagen function in Schwann cell development.
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