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Decellularized Apple-Derived Scaffolds for Bone Tissue Engineering In Vitro and In Vivo
Published on: February 23, 2024
The biomaterial influences the ossification after sinus floor elevation using tissue-engineered bone grafts.
Winnie Pradel1, Ronald Mai, Gunnar Manolo Hagedorn
1Department of Oral and Maxillofacial Surgery, University Hospital Carl Gustav Carus, Technical University Dresden, Dresden, Germany. winnie.pradel@uniklinikum-dresden.de
Biomedizinische Technik. Biomedical Engineering
|September 23, 2008
Summary
Tissue-engineered bone grafts for sinus floor elevation show potential. The preparation method of bovine bone matrix significantly impacts new bone formation and implant success in atrophic maxilla.
Area of Science:
- Oral and Maxillofacial Surgery
- Biomaterials Science
- Regenerative Medicine
Background:
- Sinus floor elevation is crucial for dental implants in the atrophic posterior maxilla.
- Autogenous bone is standard, but tissue-engineered bone grafts offer an alternative.
- Comparative studies on biomaterial influence in sinus lifts are lacking.
Purpose of the Study:
- To compare the clinical efficacy of two tissue-engineered bone graft materials for sinus floor elevation.
- To assess the influence of biomaterial preparation on bone regeneration and implant integration.
Main Methods:
- Six patients underwent eight sinus floor elevations using tissue-engineered bone grafts.
- Osteoblast-like cells were seeded on demineralised bovine bone matrix (DBBM) or solvent-dehydrated mineralised bone (SDBB) scaffolds.
- Clinical outcomes and histological analysis were evaluated up to 12 months.
Main Results:
- Primary wound healing was successful in most cases.
- Implant insertion was only possible in the SDBB group after 12 months.
- DBBM group showed fibrous tissue, while SDBB group demonstrated bone formation and scaffold encapsulation.
Conclusions:
- The preparation method of bovine bone matrix, especially mineral content and mechanical stability, influences new bone generation.
- SDBB appears more promising than DBBM for sinus floor elevation and subsequent dental implant success.
