Related Experiment Video
Updated: Jun 30, 2026

Isolation and Kv Channel Recordings in Murine Atrial and Ventricular Cardiomyocytes
Published on: March 12, 2013
CaMKII and its role in cardiac arrhythmia
Jeffrey R Erickson1, Mark E Anderson
1Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242-1109, USA.
Abstract:
Calcium/calmodulin-dependent kinase II (CaMKII) is a multifunctional serine/threonine kinase widely distributed in a number of tissue types. Activation of CaMKII has been linked to important downstream physiological processes, including apoptosis, hypertrophy, and arrhythmia in the heart. Pharmacological or genetic inhibition of CaMKII has been shown to improve health outcomes in a number of animal models. In this review, we summarize the structural and functional properties of CaMKII and detail its role in cardiac arrhythmia, structural heart disease, and sudden death.
Related Concept Videos
Mechanism of Cardiac Arrhythmias
Electrophysiology of Normal Cardiac Rhythm
Cardiac Action Potential
The cardiac action potential process involves a series of phases characterized by the movement of ions across the cardiac cell membranes, leading to the depolarization and repolarization of the cardiac myocytes.
Ionic Basis of Cardiac Action Potentials
Antiarrhythmic Drugs: Class II Agents as β-Adrenergic Blockers
G-Protein Gated Ion Channels
Sensory organs,...
Disturbances in Heart Rhythm
Arrhythmias are categorized by their speed, rhythm, and origin. A slow heart...

