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Updated: Jun 30, 2026

Induction and Assessment of Exertional Skeletal Muscle Damage in Humans
Published on: December 11, 2016
Over a millon Creatine Kinase due to a heavy work-out: A case report
110 Amsterdam Ave, Apt 306, zip 10023, New York, NY, USA. pcasares@chpnet.org.
Exercise-induced rhabdomyolysis is common, but this case involved extremely high creatine kinase levels after resuming physical activity. The patient recovered fully with aggressive hydration alone, highlighting a successful treatment approach.
Area of Science:
- Sports Medicine
- Exercise Physiology
- Clinical Case Reports
Background:
- Exercise-induced rhabdomyolysis is a recognized condition linked to strenuous physical exertion.
- Previous reports detail cases associated with weight lifting, marathon running, and overexertion in untrained individuals.
- This condition involves the breakdown of muscle tissue, releasing damaging proteins into the bloodstream.
Purpose of the Study:
- To report a unique case of exercise-induced rhabdomyolysis.
- To highlight an exceptionally high creatine kinase level in the context of exercise-induced rhabdomyolysis.
- To present a successful treatment outcome using conservative measures.
Main Methods:
- Case study of a 25-year-old Hispanic male.
- Detailed medical history focusing on recent physical activity resumption.
- Biochemical analysis including creatine kinase level measurement.
- Treatment protocol involving aggressive hydration.
Main Results:
- The patient presented with exercise-induced rhabdomyolysis after resuming regular physical activity.
- Creatine kinase levels were recorded as the highest documented in the literature for this condition.
- The patient experienced a full recovery without any complications.
- Treatment primarily consisted of aggressive hydration therapy.
Conclusions:
- Resuming physical activity after a period of inactivity can precipitate severe rhabdomyolysis.
- Aggressive hydration is an effective and sufficient treatment for exercise-induced rhabdomyolysis in select cases.
- This case expands the understanding of the spectrum and management of exercise-induced rhabdomyolysis.
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