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Related Experiment Video

Updated: Jun 30, 2026

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein

Published on: October 12, 2017

Lipoperoxidation and hemodialysis.

Rosa Ramos¹, Alberto Martínez-Castelao

¹Nephrology Department, Ciutat Sanitària i Universitària de Bellvitge, C/Feixa Llarga s/n, L'Hospitalet del Llobregat, 08907 Barcelona, Spain. 30965rrs@comb.es

Metabolism: Clinical and Experimental

|September 23, 2008

Summary

This summary is machine-generated.

Hemodialysis improved lipid profiles in patients with end-stage renal disease. While vitamin C supplementation did not show significant differences, it trended towards reducing oxidative stress markers in hemodialysis patients.

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Area of Science:

Nephrology
Cardiovascular Medicine
Biochemistry

Background:

Patients undergoing hemodialysis often experience increased oxidative stress, potentially increasing cardiovascular disease risk.
Antioxidant supplementation, particularly vitamin C, is explored for its potential benefits in mitigating this stress.

Purpose of the Study:

To assess the impact of hemodialysis on lipid and lipoprotein oxidation profiles.
To investigate the effect of vitamin C supplementation on these parameters in end-stage renal disease patients initiating hemodialysis.

Main Methods:

Forty-one end-stage renal disease patients were randomized to receive 1000 mg/day vitamin C or placebo before hemodialysis.
Lipid profiles and the susceptibility of LDL and HDL to oxidation were measured at baseline and after 1 year.

Main Results:

Hemodialysis alone improved lipid profiles, reducing total cholesterol, LDL cholesterol, and phospholipids, but also decreased HDL cholesterol.
Oxidation markers (TBARS, lipoperoxides) increased after one year of hemodialysis in both groups.
A trend towards lower oxidation products was observed in the vitamin C group, though not statistically significant.

Conclusions:

Hemodialysis may improve lipid profiles in uremic patients, despite an increase in oxidative stress markers.
Vitamin C supplementation showed a potential trend in reducing oxidation, but further research is needed due to small sample size and inconclusive results.