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Updated: Jun 30, 2026

Real-Time Quantitative Measurement of Tumor Cell Migration and Invasion Following Synthetic mRNA Transfection
Published on: June 23, 2023
Collagen XVI expression is upregulated in glioblastomas and promotes tumor cell adhesion
Volker Senner1, Sabine Ratzinger, Sonja Mertsch
1Institute of Neuropathology, University Hospital Muenster, Domagkstrasse 19, D-48149 Muenster, Germany. senner@uni-muenster.de
Abstract:
The poor prognosis of glioblastoma patients is related to diffuse brain invasion and interaction of tumor cells with extracellular matrices (ECM). We describe expression and function of the FACIT-collagen XVI in glioblastomas. We found upregulation of collagen XVI mRNA as well as protein in glioblastomas as compared to normal cortex. SiRNA knockdown resulted in decreased cell adhesion whereas increased adhesion was observed on surfaces coated with collagen XVI. The migration of glioblastoma cells on this substrate remained unchanged. Our results demonstrate de-novo expression of collagen XVI in glioblastomas as part of the tumor specific remodeling of the ECM.
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