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Antibody-based identification of cell surface antigens: targets for cancer therapy

Deryk T Loo1, Jennie P Mather

  • 1Raven Biotechnologies, Inc., One Corporate Drive, South San Francisco, CA 94080, USA.

Current Opinion in Pharmacology
|September 23, 2008
PubMed

Insights

Identifying novel cell surface antigens on intact cancer cells is key for new cancer therapies. Antibody technologies are discovering cancer-specific targets and generating therapeutic monoclonal antibodies (MAbs) for improved treatments.

Area of Science:

  • Oncology
  • Immunology
  • Biotechnology

Background:

  • Novel cell surface antigens on tumor cells are critical for advancing cancer therapies.
  • Intact, viable cancer cells present antigens in their native conformation, serving as a valuable source for discovery.

Purpose of the Study:

  • To identify novel cancer-specific antigen targets using cell-based approaches.
  • To generate therapeutic monoclonal antibodies (MAbs) against these identified antigens.

Main Methods:

  • Utilizing antibody-based technologies to probe the surface of intact cancer cells.
  • Employing cell-based strategies for the development of epitope-specific MAbs.

Main Results:

  • Discovery of new cancer-specific protein and nonprotein targets.
  • Generation of monoclonal antibodies (MAbs) targeting cancer-specific epitopes.

Conclusions:

  • Cell-based approaches are effective for identifying novel cancer antigens and developing therapeutic MAbs.
  • This strategy is poised to revolutionize the discovery of targets for antibody-based cancer therapies.

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