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Brain Imaging Investigation of the Neural Correlates of Emotional Autobiographical Recollection
Published on: August 26, 2011
Neuroimaging and cognitive changes during déjà vu
Norbert Kovacs1, Tibor Auer, Istvan Balas
1Department of Neurology, University of Pecs, Pecs, Hungary. kovacsnorbert06@gmail.com
Epilepsy & Behavior : E&B
|September 23, 2008
Summary
Deep brain stimulation (DBS) in a patient with hemidystonia evoked déjà vu (DV), revealing hyperperfusion in the hippocampus and limbic structures. This suggests mesiotemporal involvement in déjà vu experiences.
Area of Science:
- Neuroscience
- Neurology
- Epileptology
Background:
- The etiology and physiological function of déjà vu (DV) remain unclear in healthy individuals.
- The underlying pathophysiology of DV-type epileptic aura is also not fully understood.
Purpose of the Study:
- To investigate the neurobiological basis of déjà vu (DV) by describing its occurrence during deep brain stimulation (DBS).
- To explore the role of mesiotemporal structures in the generation of DV.
Main Methods:
- A case study of a 22-year-old woman with hemidystonia undergoing DBS of the left internal globus pallidus.
- Neuropsychological testing and single-photon-emission computed tomography (SPECT) were conducted during DBS-evoked DV episodes and control conditions.
Main Results:
- Deep brain stimulation (DBS) at specific settings reproducibly elicited déjà vu (DV) episodes.
- SPECT imaging during DBS-evoked DV showed hyperperfusion in the right hippocampus and other limbic areas.
- Neuropsychological assessments indicated nonverbal memory disturbances during evoked DV episodes.
Conclusions:
- The findings support the involvement of mesiotemporal structures in the pathogenesis of déjà vu (DV).
- Hypotheses include the influence of individual neuroanatomy and disruptions in gamma oscillations or the dopaminergic system on DBS-elicited DV.
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