Related Experiment Video
Updated: Jun 30, 2026

Directed Differentiation of Hemogenic Endothelial Cells from Human Pluripotent Stem Cells
Published on: March 31, 2021
Endothelium as master regulator of organ development and growth
Daniela Tirziu1, Michael Simons
1Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA.
Abstract:
Development of the vasculature is one of the earliest events during embryogenesis, preceding organ formation. Organogenesis requires a complex set of paracrine signals between the vasculature and the developing nonvascular tissues to support differentiation and organ growth. However, the role of endothelium in controlling organ growth and, ultimately, size is little-understood. In this review, we summarize new data regarding the endothelium function in order to provide a more comprehensive understanding of the communication between the endothelium and the organ's tissue.
Related Concept Videos
Regulation of Angiogenesis and Blood Supply
Development of Blood Vessels
The initial formation of this system is facilitated by the small amount of yolk present in the ovum and yolk sac. Blood vessels originate from...
Overview of the Vascular System
Structure of Blood Vessels
Mechanism of Angiogenesis
Role of Ephrin-Eph Signalling in Intestinal Stem Cell Renewal

