Jove
Visualize
Contact Us

Related Experiment Video

Updated: Jun 30, 2026

Protocol for Dengue Infections in Mosquitoes (A. aegypti) and Infection Phenotype Determination
15:25

Protocol for Dengue Infections in Mosquitoes (A. aegypti) and Infection Phenotype Determination

Published on: July 4, 2007

A two-age-classes dengue transmission model.

A K Supriatna1, E Soewono, S A van Gils

  • 1Department of Mathematics, Universitas Padjadjaran, Jl. Raya Bandung-Sumedang Km 21, Jatinangor, Sumedang, West Java 45363, Indonesia. aksupriatna@bdg.centrin.net.id

Mathematical Biosciences
|September 23, 2008
PubMed
Summary

Vaccinating children against dengue can be counterproductive if it prolongs infectiousness, paradoxically increasing disease spread. Screening before vaccination is crucial, as age-based models reveal complex outcomes beyond simple rules.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A model incorporating combined RTIs and PIs therapy during early HIV-1 infection.

Mathematical biosciences·2017
Same author

On local bifurcations in neural field models with transmission delays.

Journal of mathematical biology·2012
Same author

Functional neuronal activity and connectivity within the subthalamic nucleus in Parkinson's disease.

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology·2012
Same author

From Parkinsonian thalamic activity to restoring thalamic relay using deep brain stimulation: new insights from computational modeling.

Journal of neural engineering·2011
Same author

The pedunculopontine nucleus as an additional target for deep brain stimulation.

Neural networks : the official journal of the International Neural Network Society·2011
Same author

Bifurcation and stability analysis in musculoskeletal systems: a study in human stance.

Biological cybernetics·2004
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Area of Science:

  • Epidemiology
  • Mathematical Modeling
  • Public Health

Background:

  • Dengue transmission is influenced by population age structure.
  • Vaccination strategies often target specific age groups, particularly children.
  • Existing dengue models may not fully capture age-dependent vaccination effects.

Purpose of the Study:

  • To analyze a two-age-class dengue transmission model incorporating vaccination.
  • To investigate the conditions under which vaccination might paradoxically increase dengue transmission.
  • To evaluate the impact of age-specific vaccination on disease dynamics.

Main Methods:

  • Development of a mathematical model dividing the human population into two age classes.
  • Analysis of a threshold number equivalent to the basic reproduction number (R0).

More Related Videos

Vector Competence Analyses on Aedes aegypti Mosquitoes using Zika Virus
10:35

Vector Competence Analyses on Aedes aegypti Mosquitoes using Zika Virus

Published on: May 31, 2020

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease
04:23

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease

Published on: April 28, 2019

Related Experiment Videos

Last Updated: Jun 30, 2026

Protocol for Dengue Infections in Mosquitoes (A. aegypti) and Infection Phenotype Determination
15:25

Protocol for Dengue Infections in Mosquitoes (A. aegypti) and Infection Phenotype Determination

Published on: July 4, 2007

Vector Competence Analyses on Aedes aegypti Mosquitoes using Zika Virus
10:35

Vector Competence Analyses on Aedes aegypti Mosquitoes using Zika Virus

Published on: May 31, 2020

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease
04:23

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease

Published on: April 28, 2019

  • Simulation of vaccination strategies with a focus on the child age class.

    • Main Results:

    • Vaccination can be counterproductive if it exacerbates infectiousness in children, increasing the basic reproduction number.
    • This paradoxical effect occurs when the worsening of the condition exceeds a threshold determined by demographic and epidemiological parameters.
    • If vaccination increases virulence leading to symptomatic disease, it remains productive.
    • Screening before vaccination is recommended in both scenarios.

    Conclusions:

    • Age-structured dengue models reveal complexities in vaccination impact.
    • The effectiveness of dengue vaccination depends on age-specific effects and screening.
    • Standard vaccination rules of thumb may be obscured by age-related factors in disease transmission.