Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Bone Remodeling and Repair

Bone Remodeling and Repair

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...

Tissue Transplantation

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...

Bone Marrow Sampling and Transplants

Bone Marrow Sampling and Transplants

Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

The economic burden in terms of cost of illness and generic health-related quality of life of posttraumatic long bone non-unions among the adult population of the Netherlands from a societal perspective.

European journal of trauma and emergency surgery : official publication of the European Trauma Society·2026

Same author

Unlocking high-intensity performance thresholds through ventilatory signatures in the ECG.

Scientific reports·2026

Same author

Relationship between fecal egg counts and intestinal nematode burden of naturally infected dogs, derived from records of anthelmintic efficacy studies.

Veterinary parasitology·2025

Same author

Patient-recorded indexing measurements (PRIMS) - study protocol of a prospective observational cohort study to improve the accuracy of the diagnosis of cancer cachexia.

BMC cancer·2025

Same author

Assessing diagnostic accuracy: <sup>18</sup>F-FDG PET-CT scans in low-grade infection detection among post-traumatic long bone non-unions; a literature review and clinical data.

Injury·2024

Same author

Evaluation of an Image-based Classification Model to Identify Glioma Subtypes Using Arterial Spin Labeling Perfusion MRI On the Publicly Available UCSF Glioma Dataset.

Clinical neuroradiology·2024

Search research articles

Related Experiment Video

Updated: Jun 30, 2026

Site-Directed Immobilization of Bone Morphogenetic Protein 2 to Solid Surfaces by Click Chemistry

Site-Directed Immobilization of Bone Morphogenetic Protein 2 to Solid Surfaces by Click Chemistry

Published on: March 29, 2018

Allograft and bone morphogenetic proteins: an overview.

T J Blokhuis¹, T Lindner

¹Department of Surgery/Traumatology, University Nijmegen Medical Center, Nijmegen, The Netherlands. T.Blokhuis@chir.umcn.nl

|September 23, 2008

Summary

Combining allograft bone grafts with bone morphogenetic proteins (BMPs) can enhance their biological activity and effectiveness in orthopaedic and trauma surgery, potentially reducing failure rates.

More Related Videos

Computed Tomography and Optical Imaging of Osteogenesis-angiogenesis Coupling to Assess Integration of Cranial Bone Autografts and Allografts

Computed Tomography and Optical Imaging of Osteogenesis-angiogenesis Coupling to Assess Integration of Cranial Bone Autografts and Allografts

Published on: December 22, 2015

Bone Conditioned Medium: Preparation and Bioassay

Bone Conditioned Medium: Preparation and Bioassay

Published on: July 8, 2015

Related Experiment Videos

Last Updated: Jun 30, 2026

Site-Directed Immobilization of Bone Morphogenetic Protein 2 to Solid Surfaces by Click Chemistry

Site-Directed Immobilization of Bone Morphogenetic Protein 2 to Solid Surfaces by Click Chemistry

Published on: March 29, 2018

Computed Tomography and Optical Imaging of Osteogenesis-angiogenesis Coupling to Assess Integration of Cranial Bone Autografts and Allografts

Computed Tomography and Optical Imaging of Osteogenesis-angiogenesis Coupling to Assess Integration of Cranial Bone Autografts and Allografts

Published on: December 22, 2015

Bone Conditioned Medium: Preparation and Bioassay

Bone Conditioned Medium: Preparation and Bioassay

Published on: July 8, 2015

Area of Science:

Orthopaedic Surgery
Biomaterials Science
Regenerative Medicine

Background:

Allograft bone grafts are widely used in orthopaedic and trauma procedures.
Current processing methods can limit the biological activity of allografts.
Safety concerns are also associated with allograft use.

Purpose of the Study:

To review the combined application of allograft and bone morphogenetic proteins (BMPs).
To summarize current literature on allograft/BMP combinations for enhanced effectiveness.
To explore the potential of BMPs in improving allograft performance.

Main Methods:

Literature review of studies on allograft and BMP combination therapies.
Analysis of biological activity and clinical effectiveness data.
Synthesis of current viewpoints on allograft/BMP applications.

Main Results:

Combining allografts with osteoinductive substances, particularly BMPs, shows promise for improving outcomes.
BMPs may enhance the osteoinductive potential of allografts.
This combination could lead to decreased failure rates in surgical applications.

Conclusions:

Allograft/BMP combinations represent a promising strategy in orthopaedic and trauma surgery.
Further research and clinical application of BMP-enhanced allografts are warranted.
Optimizing allograft processing with biologics like BMPs is key to maximizing their clinical utility.