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Steroidogenesis during postnatal development in the mouse ovary.

M A Mannan1, P J O'Shaughnessy

  • 1Department of Veterinary Basic Sciences, Royal Veterinary College, London.

The Journal of Endocrinology
|July 1, 1991
PubMed
Summary
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Early mouse ovary development shows limited steroid production at birth, with significant increases in progesterone and androstenedione starting around day 7, linked to follicular growth and thecal cell differentiation.

Area of Science:

  • Reproductive Biology
  • Developmental Biology
  • Endocrinology

Background:

  • Follicular formation and development in mice are primarily postnatal processes.
  • Ovarian steroidogenesis in early life reflects changing follicular activity during folliculogenesis.

Purpose of the Study:

  • To investigate changes in basal and gonadotropin-stimulated ovarian steroid production in mice during early postnatal development.
  • To assess the responsiveness of developing mouse ovaries to gonadotropins, dibutyryl cyclic AMP (dbcAMP), and 22R-hydroxycholesterol.

Main Methods:

  • In vitro incubation of ovaries from mice aged 1, 3, 5, 7, 10, and 15 days.
  • Measurement of basal progesterone and androstenedione production.
  • Assessment of steroidogenic response to luteinizing hormone (LH), follicle-stimulating hormone (FSH), dbcAMP, and 22R-hydroxycholesterol.

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Main Results:

  • Undetectable steroid production on days 1 and 3, with minimal cholesterol side-chain cleavage (CSCC) activity.
  • Significant increase in ovarian steroid production from day 7 onwards, associated with an 80-fold increase in CSCC activity.
  • LH stimulated steroid production from day 7, while FSH showed an effect on progesterone by day 15. Follicular development correlated with steroidogenic capacity.

Conclusions:

  • Mouse ovarian steroidogenesis is minimal at birth and gradually increases postnatally.
  • The development of secondary follicles and thecal tissue is crucial for the rise in ovarian steroid production.
  • Gonadotropin responsiveness, particularly to LH, emerges and strengthens during early postnatal ovarian development.