Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Glucose Absorption Into the Small Intestine

Glucose Absorption Into the Small Intestine

Complex carbohydrates consumed cannot be absorbed into the small intestine in their original form. First, they must be hydrolyzed to a monosaccharide form such as glucose or galactose. These monosaccharides are then transported across the intestinal membrane and into the blood via transcellular transport. The intestinal epithelial cells allow the movement of these monosaccharides with a defined 'entry' through membrane transporter proteins present on their apical membrane and 'exit' via the...

Glucose Transporters

Glucose Transporters

Glucose transporters facilitate the transport of glucose across the cell membrane. In addition to glucose, some glucose transporters can also aid the movement of other hexoses such as fructose, mannose, and galactose.
Facilitated diffusion-glucose transporters (GLUTs) are encoded by the solute-linked carrier (SLC) family 2, subfamily A gene family, or SLC2A. The 14 GLUT protein members are distributed into three classes:

Glycocalyx and its Functions

Glycocalyx and its Functions

The glycocalyx is a carbohydrate-rich, fuzzy-appearing layer on the outer surface of the cell membrane. It is highly hydrophilic, because of this it attracts large amounts of water to the cell's surface. This aids the cell's interaction with the watery environment and also helps it to obtain substances dissolved in the water. It is also important for cell identification, self/non-self determination, and embryonic development and is used in cell-to-cell attachments to form tissues.
Components of...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Silicon-supported 2D conductive metal-organic framework nanorod arrays for alkaline water and urea electrooxidation.

Chemical communications (Cambridge, England)·2026

Same author

Underwater mussel-inspired adhesive formed by simple coacervation.

Soft matter·2026

Same author

Tubed or tubeless insulin pumps? A retrospective real-world analysis of national French health data.

BMJ open diabetes research & care·2026

Same author

Imaging hole transport at catalyst-coated MIS photoanodes for water splitting under high-intensity illumination.

Chemical science·2026

Same author

How PNIPAM Microgel Architecture Controls Pickering Foam Formation.

Small (Weinheim an der Bergstrasse, Germany)·2026

Same author

Pickering emulsions stabilized by microgels: Three regimes of surface coverage.

Journal of colloid and interface science·2025

Search research articles

Related Experiment Video

Updated: Jun 30, 2026

Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release

Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release

Published on: February 13, 2016

Glucose-responsive microgels with a core-shell structure.

Véronique Lapeyre¹, Christophe Ancla, Bogdan Catargi

¹Université Bordeaux, Institut des Sciences Moléculaires, ENSCPB, 16 Av. Pey Berland, Pessac Cedex F-33607, France.

Journal of Colloid and Interface Science

|September 23, 2008

Summary

New core-shell microgels respond to both temperature and glucose. This glucose-responsive material can control insulin release, offering potential for advanced drug delivery systems.

More Related Videos

Interlinked Macroporous 3D Scaffolds from Microgel Rods

Interlinked Macroporous 3D Scaffolds from Microgel Rods

Published on: June 16, 2022

Controlled Synthesis and Fluorescence Tracking of Highly Uniform Poly(N-isopropylacrylamide) Microgels

Controlled Synthesis and Fluorescence Tracking of Highly Uniform Poly(N-isopropylacrylamide) Microgels

Published on: September 8, 2016

Related Experiment Videos

Last Updated: Jun 30, 2026

Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release

Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release

Published on: February 13, 2016

Interlinked Macroporous 3D Scaffolds from Microgel Rods

Interlinked Macroporous 3D Scaffolds from Microgel Rods

Published on: June 16, 2022

Controlled Synthesis and Fluorescence Tracking of Highly Uniform Poly(N-isopropylacrylamide) Microgels

Controlled Synthesis and Fluorescence Tracking of Highly Uniform Poly(N-isopropylacrylamide) Microgels

Published on: September 8, 2016

Area of Science:

Materials Science
Polymer Chemistry
Biomedical Engineering

Background:

Development of smart microgels for controlled release applications.
Need for stimuli-responsive materials that can respond to physiological conditions.

Purpose of the Study:

Synthesize and characterize novel thermoresponsive core-shell microgels with a glucose-responsive shell.
Investigate the influence of glucose on microgel swelling and thermal properties.
Demonstrate the application of these microgels for glucose-regulated insulin delivery.

Main Methods:

Synthesis of poly(N-isopropylacrylamide) (pNIPAM) core and pNIPAM-co-acrylamidophenylboronic acid (pNIPAM-co-APBA) shell microgels.
Dynamic light scattering (DLS) for structural elucidation.
Thermal property analysis.
Insulin encapsulation and release studies.

Main Results:

Successfully synthesized core-shell microgels with distinct thermoresponsive and glucose-responsive behaviors.
Demonstrated glucose-induced swelling of the shell, leading to core expansion.
Showcased glucose-dependent regulation of insulin release from encapsulated microgels at physiological pH and salinity.

Conclusions:

The synthesized core-shell microgels offer tunable swelling and release properties based on temperature and glucose concentration.
This system provides a promising platform for developing glucose-responsive drug delivery systems, particularly for insulin therapy.
The dual responsiveness and operation at physiological conditions highlight the potential for in vivo applications.