Low QRS voltage and its causes
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Updated: Jun 30, 2026

Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation
Published on: January 16, 2019
1Mount Sinai School of Medicine, New York University, New York, NY, USA. madiasj@nychhc.org
Abstract:
Electrocardiographic low QRS voltage (LQRSV) has many causes, which can be differentiated into those due to the heart's generated potentials (cardiac) and those due to influences of the passive body volume conductor (extracardiac). Peripheral edema of any conceivable etiology induces reversible LQRSV, reduces the amplitude of the P waves and T waves, decreases the duration of P waves, QRS complexes, and QT intervals, and alters in turn the measurements of the signal-averaged electrocardiogram and T wave alternans, all with enormous clinical implications.
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