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Related Concept Videos

Modified-Release Drug Delivery Systems: Drug Release Characteristics01:22

Modified-Release Drug Delivery Systems: Drug Release Characteristics

Drug release from modified-release dosage forms is designed to achieve specific therapeutic effects by controlling the rate and extent of drug release. The classification of these drug release systems is based on key pharmacokinetic assumptions: drug disposition follows first-order kinetics, drug release is the rate-limiting step in absorption, and the released drug is rapidly and completely absorbed.There are four major models of drug release patterns. The first model is the slow zero-order...
Modified-Release Drug Delivery Systems: Rate-Programmed II01:19

Modified-Release Drug Delivery Systems: Rate-Programmed II

Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
Bioavailability Enhancement: Drug Stability Enhancement and GI Retention01:05

Bioavailability Enhancement: Drug Stability Enhancement and GI Retention

Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...
Modified-Release Drug Delivery Systems: Stimuli-Activated01:30

Modified-Release Drug Delivery Systems: Stimuli-Activated

Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also called...
Modified-Release Drug Delivery Systems: Rate-Programmed I01:22

Modified-Release Drug Delivery Systems: Rate-Programmed I

Rate-programmed drug delivery systems (DDS) are designed to release drugs at specific, controlled rates to maintain consistent therapeutic levels. These systems are categorized based on their release mechanisms, including dissolution-controlled DDS, diffusion-controlled DDS, and combined dissolution-diffusion-controlled DDS.In dissolution-controlled DDS, the release rate depends on the slow dissolution of the drug itself or the surrounding matrix. Drugs with inherently slow dissolution rates,...
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Modified-Release Drug Delivery Systems: Bioavailability

Modified-release (MR) dosage forms are designed to extend drug release over time, thereby maintaining stable plasma concentrations and reducing dosing frequency. However, their bioavailability is typically below 100% due to incomplete drug release and presystemic metabolism, and limitations in drug permeability across the gastrointestinal epithelium, all of which can restrict the fraction of the drug reaching systemic circulation. Consequently, studying the in vivo bioavailability of MR...

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Direct and Indirect Culture Methods for Studying Biodegradable Implant Materials In Vitro
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Published on: April 15, 2022

Strontium modified biocements with zero order release kinetics.

Mohammad Hamdan Alkhraisat1, Claus Moseke, Luis Blanco

  • 1Departamento de Química Física II, Facultad de Farmacia, UCM, 28040 Madrid, Spain.

Biomaterials
|September 23, 2008
PubMed
Summary
This summary is machine-generated.

Strontium-substituted beta-TCP cements surprisingly form monetite, unlike strontium-free cements which form brushite. These strontium-releasing cements support osteoblast cell growth and function.

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Biological Compatibility Profile on Biomaterials for Bone Regeneration
10:28

Biological Compatibility Profile on Biomaterials for Bone Regeneration

Published on: November 16, 2018

Area of Science:

  • Biomaterials Science
  • Materials Chemistry
  • Biomineralization

Background:

  • Beta-tricalcium phosphate (β-TCP) is a key biomaterial in bone regeneration.
  • Strontium substitution is explored to enhance biomaterial properties.

Purpose of the Study:

  • To synthesize and characterize strontium-substituted β-TCP (Sr-β-TCP).
  • To investigate the effect of Sr-β-TCP on cement setting products and ion release.
  • To evaluate the cytocompatibility of Sr-β-TCP cements.

Main Methods:

  • Synthesis of Sr-β-TCP via calcination of powder mixtures.
  • Cement formation by reacting Sr-β-TCP with monocalcium phosphate monohydrate (MCPM).
  • Analysis of setting products using X-ray diffraction.
  • Strontium ion release studies under dynamic conditions.
  • In vitro cytocompatibility testing with human osteoblast cell line (hFOB1.19).

Main Results:

  • Sr-β-TCP cements formed monetite (CaHPO₄), while Sr-free cements formed brushite (CaHPO₄·2H₂O).
  • Strontium ions (Sr²⁺) were released in doses of 12–30 ppm with zero-order kinetics.
  • Sr-β-TCP cements demonstrated comparable cytocompatibility to Sr-free cements for osteoblast growth and function.

Conclusions:

  • Strontium substitution in β-TCP influences the phase formation of calcium phosphate cements.
  • Sr-β-TCP cements provide a suitable environment for osteoblast proliferation and function.
  • These findings suggest potential applications of Sr-β-TCP cements in bone tissue engineering.