Related Experiment Video
Updated: Jun 30, 2026

Examination of Oral Candida Infection in Primary Sjögren's Syndrome Patients
Published on: March 1, 2024
Recurrent oral ulceration: aphthous-like ulcers in periodic syndromes
1Eastman Dental Institute, University College London, London, UK. crispian.scully@eastman.ucl.ac.uk
Abstract:
Recurrent oral ulceration that clinically resembles recurrent aphthous stomatitis but presents atypically, including commencement after adolescence, with fever, with a strong family history, or failing to resolve with age, has been termed aphthous-like ulceration (ALU). It may be seen in some immunodeficiency states, chronic viral infections, rheumatologic disorders, skin diseases, and the periodic syndromes. The periodic syndromes, considered to be the prototypic autoinflammatory diseases, present with recurrent short attacks of myalgia, arthralgia, rashes, abdominal pain, lymphadenopathy, and fever. Several of the syndromes can result in amyloidosis. Genetic studies have enhanced the clinical characterization of these conditions and elucidation of their molecular etiopathogenesis. This paper describes 2 patients with periodic syndromes presenting with ALU and reviews the present understanding of the syndromes.
Related Concept Videos
Peptic Ulcer Disease I: Introduction
An acute ulcer, marked by superficial erosion and minimal inflammation, swiftly resolves upon identifying and addressing the underlying cause. In contrast, a chronic ulcer persists, potentially eroding through the muscular wall and forming fibrous tissue.
Peptic ulcers can also be...
Peptic Ulcer Disease I: Introduction
Peptic Ulcer Disease III: Clinical Manifestations and Complications
Peptic Ulcer
Herpes
Peptic Ulcer Disease II: Pathophysiology
Damaging agents such as Helicobacter pylori, gastric acid, pepsin, and nonsteroidal anti-inflammatory drugs (NSAIDs) can weaken the mucosal defense, allowing hydrogen ions to infiltrate back and harm epithelial cells.
