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Non-Invasive Model of Neuropathogenic Escherichia coli Infection in the Neonatal Rat
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Neonatal infections in Asia.

R Tiskumara1, S H Fakharee, C Q Liu

  • 1Department of Infectious Diseases, Children's Hospital at Westmead, Westmead, NSW 2145, Australia.

Archives of Disease in Childhood. Fetal and Neonatal Edition
|September 23, 2008
PubMed
Summary
This summary is machine-generated.

Neonatal unit infections in Asia show high late-onset sepsis incidence and significant antibiotic resistance in Gram-negative bacilli. Mortality rates for neonatal sepsis were 10.4%, with late-onset sepsis having a higher incidence than in developed countries.

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Area of Science:

  • Neonatalogy
  • Infectious Diseases
  • Epidemiology

Background:

  • Neonatal unit infections pose a significant threat to infant survival.
  • Understanding the epidemiology of these infections is crucial for developing effective interventions.

Purpose of the Study:

  • To investigate the epidemiology of neonatal unit infections in Asian countries.
  • To determine the incidence, antibiotic sensitivity, and mortality associated with neonatal sepsis.

Main Methods:

  • A one-year prospective study was conducted across eight neonatal units in Asia.
  • Data collection focused on episodes of neonatal sepsis, causative organisms, antibiotic sensitivity, and patient outcomes.

Main Results:

  • 453 sepsis episodes occurred in 394 infants, with an overall mortality of 10.4%.
  • Late-onset sepsis incidence was 11.6 per 1000 live births with 8.9% mortality. Gram-negative bacilli showed high resistance (30% resistant to both gentamicin and cephalosporins).
  • Early-onset sepsis was commonly caused by Group B Streptococcus (38% of cases).

Conclusions:

  • Late-onset sepsis incidence in Asia exceeds that in resource-rich nations, though mortality and causative organisms are comparable.
  • Over half of Gram-negative bacilli isolated demonstrated antibiotic resistance, highlighting a critical challenge in treatment.
  • Targeted antibiotic stewardship and infection control measures are essential in Asian neonatal units.