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Updated: Jun 30, 2026

Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants

Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants

Published on: June 13, 2021

Postpartum thyroid measures and depressive symptomology: a pilot study.

Sarah J Breese McCoy¹, J Martin Beal, Mark E Payton

¹Department of Obstetrics and Gynecology, Oklahoma State University Center for Health Sciences, College of Osteopathic Medicine and Surgery, Office of Research, 1111 W 17th St, Tulsa, OK 74107-1898, USA. sjmccoy98@aol.com

The Journal of the American Osteopathic Association

|September 23, 2008

Summary

Postpartum thyroid measures, including thyroid-stimulating hormone (TSH) and thyroid antibodies, may correlate with depressive symptoms. These findings suggest a potential link between thyroid health and mood during the postpartum period.

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Last Updated: Jun 30, 2026

Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants

Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants

Published on: June 13, 2021

Area of Science:

Endocrinology
Psychiatry
Immunology

Background:

Postpartum depression (PPD) is linked to psychosocial factors.
Emerging evidence suggests a connection between PPD and thyroid function.

Purpose of the Study:

To investigate correlations between thyroid measures and PPD screening scores at 4 weeks postpartum.

Main Methods:

Recruited 51 adult subjects.
Administered Edinburgh Postnatal Depression Scale (EPDS) prenatally and at 4 weeks postpartum.
Collected blood samples for thyroid-stimulating hormone (TSH), free thyroxine4, thyroid peroxidase, and thyroglobulin at both intervals.

Main Results:

Higher serum TSH levels at 4 weeks postpartum correlated with higher EPDS scores.
Subjects with positive postnatal thyroid antibody tests were more likely to report higher EPDS scores.

Conclusions:

Elevated TSH levels and thyroid autoantibodies in the postpartum period may be associated with depressive symptoms.
These thyroid-related factors could contribute to the development of postpartum depression.