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Updated: Jun 30, 2026

Interventional Diagnostic Procedure: A Practical Guide for the Assessment of Coronary Vascular Function

Interventional Diagnostic Procedure: A Practical Guide for the Assessment of Coronary Vascular Function

Published on: March 15, 2022

Anticoagulation and bleeding risk after core needle biopsy.

Patricia Somerville¹, Posy J Seifert, Stamatia V Destounis

¹The Elizabeth Wende Breast Clinic, 170 Sawgrass Dr., Rochester, NY 14620, USA. psomerville@ewbc.com

AJR. American Journal of Roentgenology

|September 23, 2008

Summary

Core needle biopsy is safe for patients on anticoagulation therapy. While bruising is more common, clinically significant bleeding complications did not occur, supporting its use in anticoagulated individuals.

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Last Updated: Jun 30, 2026

Interventional Diagnostic Procedure: A Practical Guide for the Assessment of Coronary Vascular Function

Interventional Diagnostic Procedure: A Practical Guide for the Assessment of Coronary Vascular Function

Published on: March 15, 2022

Area of Science:

Oncology
Radiology
Hematology

Background:

Core needle biopsy is a common diagnostic procedure for breast lesions.
Anticoagulant medications are frequently prescribed for various medical conditions.
The safety of performing core needle biopsy in patients on anticoagulation therapy requires careful evaluation.

Purpose of the Study:

To compare bleeding complication rates after core needle biopsy in patients receiving anticoagulation therapy versus those not on anticoagulation.
To assess the overall safety of performing core needle breast biopsy in anticoagulated patients.

Main Methods:

A retrospective study analyzed 1,144 core needle biopsies performed between August 2004 and May 2007.
The study included 200 women on daily anticoagulant therapy (aspirin, warfarin, Excedrin) and 855 women not on anticoagulation.
Adverse reactions, including bruising and hematoma formation, were recorded and compared between groups.

Main Results:

A statistically significant increase in bruising was observed in the anticoagulated group (34%) compared to the non-anticoagulated group (26.5%) (p = 0.035).
No statistically significant differences were found in hematoma formation rates (6% vs. 4.2%, p = 0.274) or bruising with hematoma (5% vs. 3.7%, p = 0.413).
No clinically important bleeding complications were reported in either group.

Conclusions:

Performing core needle biopsy in patients on anticoagulation therapy is safe.
The increased rate of bruising in anticoagulated patients is not associated with clinically significant complications.
These findings support the continued use of core needle biopsy in patients requiring anticoagulation.