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Related Experiment Video

Updated: Jun 30, 2026

A 3D Organotypic Melanoma Spheroid Skin Model

A 3D Organotypic Melanoma Spheroid Skin Model

Published on: May 18, 2018

Vitiligo-like primary melanoma.

Aída Lugo-Somolinos¹, Jorge L Sánchez, María E Garcia

¹Department of Dermatology, University of North Carolina-Chapel Hill, Chapel Hill, NC, USA.

The American Journal of Dermatopathology

|September 23, 2008

Summary

Primary melanoma can rarely appear as vitiligo-like patches. This study reports two cases of melanoma in situ presenting as depigmented skin lesions, exploring potential immune system links.

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Area of Science:

Dermatology
Oncology
Immunology

Background:

Depigmented and hypopigmented macules and patches are recognized clinical features associated with primary and metastatic melanoma.
Melanoma presenting initially as a vitiliginous patch, without histopathological signs of regression, is considered a rare occurrence.

Observation:

This report details two patients diagnosed with melanoma in situ.
Both patients exhibited clinical presentations resembling vitiligo, characterized by depigmented patches.

Findings:

The study highlights the unusual presentation of melanoma in situ as vitiligo-like lesions.
It suggests a potential link between these depigmented presentations and underlying immunologic mechanisms.

Implications:

Recognizing vitiligo-like presentations in melanoma is crucial for early diagnosis and treatment.
Further research into the immunologic mechanisms may offer new insights into melanoma development and presentation.