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Probiotics and severe acute pancreatitis
Gabriele Capurso1, Massimo Marignani, Matteo Piciucchi
1Digestive and Liver Disease Unit, II Medical School, University La Sapienza, Rome, Italy.
Journal of Clinical Gastroenterology
|October 1, 2008
Summary
Probiotics (PBs) may reduce infectious complications in acute pancreatitis (AP) by supporting gut barrier integrity. Further research is needed to confirm their efficacy and safety in AP treatment.
Area of Science:
- Gastroenterology
- Microbiology
Background:
- Acute pancreatitis (AP) is a severe inflammatory condition with high mortality.
- Enteral nutrition supports gut barrier integrity, reducing bacterial translocation, a key factor in AP complications.
- Modulating intestinal flora with probiotics (PBs) is a potential therapeutic strategy for AP.
Purpose of the Study:
- To analyze existing literature on the effects of probiotic administration in acute pancreatitis.
- To evaluate evidence from human and animal studies regarding probiotics in AP treatment.
- To highlight the current evidence and identify gaps in knowledge regarding probiotics for AP.
Main Methods:
- Literature review of human and animal model studies.
- Analysis of data evaluating the impact of probiotic administration on AP outcomes.
- Assessment of evidence for reduced infectious complications.
Main Results:
- Probiotic administration in AP may offer advantages in reducing infectious complications.
- Evidence suggests a potential benefit of probiotics as an adjunct therapy in AP.
- Current guidelines do not recommend or cite the use of probiotics in AP.
Conclusions:
- Probiotics show a potential role in reducing infectious complications in acute pancreatitis.
- Larger, rigorously designed studies are required to establish the efficacy and safety of probiotics in AP.
- Further research is needed to support the integration of probiotics into AP management guidelines.
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