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Isolation of Adipogenic and Fibro-Inflammatory Stromal Cell Subpopulations from Murine Intra-Abdominal Adipose Depots
Published on: August 16, 2020
The inflammatory process of adipose tissue
1Department of Medicine, University of Leipzig, Leipzig, Germany. bluma@medizin.uni-leipzig.de
Pediatric Endocrinology Reviews : PER
|September 23, 2008
Summary
Obesity drives inflammation, worsening insulin resistance and related diseases. Understanding this link in adipose tissue is key to developing new treatments for obesity complications.
Area of Science:
- Metabolic disease
- Immunology
- Endocrinology
Background:
- Obesity and inflammation are closely linked in diseases like insulin resistance, diabetes, atherosclerosis, and non-alcoholic fatty liver disease.
- Obesity is characterized by increased circulating inflammatory factors and immune cell infiltration in adipose tissue, suggesting it's an inflammatory condition.
Purpose of the Study:
- To explore the integrated role of obesity and inflammation in metabolic disease pathogenesis.
- To understand the mechanisms by which adipose tissue contributes to obesity-induced inflammation and insulin resistance.
Main Methods:
- Review of existing studies on obesity, inflammation, and immune cell infiltration in human adipose tissue.
- Analysis of autocrine, paracrine, and endocrine signaling pathways involved in adipose tissue insulin resistance.
Main Results:
- Obesity can induce a pro-inflammatory state, impairing insulin sensitivity in adipose tissue, muscle, and liver.
- Adipose tissue immune cell infiltration may cause local insulin resistance, contributing to systemic insulin sensitivity reduction.
- Obesity-induced inflammation might be a compensatory response to increased adipose tissue turnover, potentially offering protection.
Conclusions:
- Adipose tissue plays a critical role in the relationship between obesity and chronic inflammation.
- Deciphering the molecular mechanisms of obesity-induced inflammation could reveal novel therapeutic targets for obesity-related complications.
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