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Updated: Jun 30, 2026

Whole-body Mass Spectrometry Imaging by Infrared Matrix-assisted Laser Desorption Electrospray Ionization (IR-MALDESI)
Published on: March 24, 2016
Infrared Mueller matrix acquisition and preprocessing system
Arthur H Carrieri1, David J Owens, Jonathan C Schultz
1U.S. Army Research, Development, and Engineering Command, Edgewood Chemical Biological Center, Research and Technology Directorate, ATTN: AMSRD-ECB-RT-DL, 5183 Blackhawk Road, Aberdeen Proving Ground, Maryland 21010-5424, USA. arthur.carrieri@us.army.mil
Abstract:
An analog Mueller matrix acquisition and preprocessing system (AMMS) was developed for a photopolarimetric-based sensor with 9.1-12.0 microm optical bandwidth, which is the middle infrared wavelength-tunable region of sensor transmitter and "fingerprint" spectral band for chemical-biological (analyte) standoff detection. AMMS facilitates delivery of two alternate polarization-modulated CO(2) laser beams onto subject analyte that excite/relax molecular vibrational resonance in its analytic mass, primes the photoelastic-modulation engine of the sensor, establishes optimum throughput radiance per backscattering cross section, acquires Mueller elements modulo two laser beams in hexadecimal format, preprocesses (normalize, subtract, filter) these data, and formats the results into digitized identification metrics. Feed forwarding of formatted Mueller matrix metrics through an optimally trained and validated neural network provides pattern recognition and type classification of interrogated analyte.
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