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Related Concept Videos

Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids01:25

Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids

Inhaled corticosteroids (ICS) are anti-inflammatory drugs used primarily in treating persistent asthma and providing long-term maintenance. They target the bronchial mucosa, the lining of the airways, to control inflammation, a critical factor in asthma progression and exacerbation.
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
Antiasthma Drugs: Leukotriene Modifiers01:19

Antiasthma Drugs: Leukotriene Modifiers

Leukotriene modifiers, or cysteinyl leukotriene receptor antagonists, are medications used to manage chronic asthma. These agents target specific inflammatory mediators produced during arachidonic acid metabolism, an essential process in generating inflammation in the body.
Leukotriene modifiers work through two distinct mechanisms:
Antiasthma Drugs: β2-Adrenoceptor Agonists01:25

Antiasthma Drugs: β2-Adrenoceptor Agonists

Bronchodilators are critical in managing asthma, a chronic respiratory condition characterized by airway constriction due to inflammation and hyper-reactivity. Specifically, bronchodilators ease this constriction by relaxing the bronchial muscles, facilitating easier breathing.
One class of bronchodilators includes β2-adrenoceptor agonists. These agents target the β2-adrenoceptors located on bronchial smooth muscle cells. By stimulating these receptors, β2-agonists induce relaxation in these...
Drug Delivery: Miscellaneous Routes01:22

Drug Delivery: Miscellaneous Routes

Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs through the...
Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
COPD: Management Using Bronchodilators and Corticosteroids01:26

COPD: Management Using Bronchodilators and Corticosteroids

Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...

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Related Experiment Video

Updated: Jun 30, 2026

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
11:39

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

Published on: July 11, 2013

Clobetasol propionate--where, when, why?

Ragna Pels1, Wolfram Sterry, Jürgen Lademann

  • 1Department of Dermatology, Polikum Friedenau, Berlin, Germany. ragna.pels@friedenau.polikum.de

Drugs of Today (Barcelona, Spain : 1998)
|September 23, 2008
PubMed
Summary

Clobetasol propionate is a potent topical steroid for skin conditions like psoriasis and atopic dermatitis. While effective, it has side effects and requires careful patient instruction for safe use.

Area of Science:

  • Dermatology
  • Pharmacology

Background:

  • Clobetasol propionate is the most potent topical corticosteroid.
  • It is used for various skin diseases including atopic dermatitis, psoriasis, and vulvar lichen sclerosus.
  • Current therapy is primarily symptomatic, with preventive effects noted only for vulvar lichen sclerosus.

Purpose of the Study:

  • To review the therapeutic applications, mechanisms of action, and side effects of clobetasol propionate.
  • To highlight the importance of proper patient education and physician consideration in prescribing this potent medication.

Main Methods:

  • Literature review of clobetasol propionate's properties and clinical use.
  • Analysis of its anti-inflammatory, immunosuppressive, and antimitotic effects.
  • Examination of available dosage forms and their impact on patient compliance.

Related Experiment Videos

Last Updated: Jun 30, 2026

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
11:39

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

Published on: July 11, 2013

Main Results:

  • Clobetasol propionate demonstrates significant anti-inflammatory, immunosuppressive, and antimitotic actions.
  • Seven dosage forms exist, potentially influencing patient adherence.
  • High potency is associated with local (e.g., skin atrophy) and systemic side effects (e.g., HPA axis suppression).

Conclusions:

  • Clobetasol propionate is a highly effective but potent topical steroid requiring careful management.
  • Physicians must educate patients thoroughly on its application, risks, and benefits.
  • Informed patient use is crucial to maximize therapeutic outcomes and minimize adverse effects.