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Related Experiment Video

Updated: Jun 30, 2026

Three-Dimensional Cell Culture Models to Investigate the Epithelial Barrier in Eosinophilic Esophagitis

Three-Dimensional Cell Culture Models to Investigate the Epithelial Barrier in Eosinophilic Esophagitis

Published on: May 10, 2024

[Eosinophilia--a challenging differential diagnosis].

Mandy Seifert¹, Jens Gerth, Mieczyslaw Gajda

¹Klinik für Innere Medizin III, Friedrich-Schiller-Universität Jena, Jena, Germany.

Medizinische Klinik (Munich, Germany : 1983)

|September 23, 2008

Summary

Hypereosinophilic syndrome can mimic other conditions and affect multiple organs. Prompt diagnosis and treatment, guided by new classifications, are crucial for patient recovery and health.

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Murine Model of Allergen Induced Asthma

Murine Model of Allergen Induced Asthma

Published on: May 14, 2012

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Last Updated: Jun 30, 2026

Three-Dimensional Cell Culture Models to Investigate the Epithelial Barrier in Eosinophilic Esophagitis

Three-Dimensional Cell Culture Models to Investigate the Epithelial Barrier in Eosinophilic Esophagitis

Published on: May 10, 2024

Murine Model of Allergen Induced Asthma

Murine Model of Allergen Induced Asthma

Published on: May 14, 2012

Area of Science:

Internal Medicine
Hematology
Pathology

Background:

Eosinophilia is common, with allergies and parasitic infections as primary causes.
Rarely, eosinophilia is linked to pulmonary issues, malignancies, gastroenteritis, and autoimmune disorders.
A 2006 classification aimed to simplify hypereosinophilic syndrome diagnosis and therapy.

Observation:

A 22-year-old male presented with severe abdominal pain, neutrophilic leukocytosis, marked eosinophilia, thrombocytopenia, and elevated CRP.
The patient developed deep venous thrombosis, pulmonary embolism, embolic pneumonia, and a characteristic rash post-surgery.
Bone marrow analysis revealed eosinophilic granulocytes and hypercellularity without blasts; extensive testing excluded infections, neoplasms, and autoimmune diseases.

Findings:

A diagnosis of undefined hypereosinophilic syndrome with multi-organ involvement was made.
Oral prednisolone treatment rapidly normalized eosinophilia.
The patient fully recovered within 6 months of diagnosis and treatment cessation.

Implications:

This case highlights the diverse presentations of hypereosinophilic syndrome, emphasizing the need for a broad differential diagnosis.
The 2006 pathophysiological classification aids in improving diagnosis and therapeutic strategies for this rare condition.
Early recognition and management are key for favorable outcomes in hypereosinophilic syndrome.