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Related Concept Videos

Stem Cell Culture01:17

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
Induced Pluripotent Stem Cells01:06

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic cells are...
Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore called induced pluripotent stem...
Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore called induced pluripotent stem...
Embryonic Stem Cells00:58

Embryonic Stem Cells

Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
Embryonic Stem Cells00:57

Embryonic Stem Cells

Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...

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Related Experiment Video

Updated: Jun 30, 2026

Reprogramming Primary Amniotic Fluid and Membrane Cells to Pluripotency in Xeno-free Conditions
09:34

Reprogramming Primary Amniotic Fluid and Membrane Cells to Pluripotency in Xeno-free Conditions

Published on: November 27, 2017

[Stem cells--cloning, plasticity, bioethic].

Pamina Pflegerl1, Thomas Keller, Brigitte Hantusch

  • 1Klinisches Institut für Pathologie an der Medizinischen Universität in Wien, Osterreich.

Wiener Medizinische Wochenschrift (1946)
|September 23, 2008
PubMed
Summary
This summary is machine-generated.

Embryonic stem cells (ESC) offer therapeutic potential but carry tumorigenesis risks and ethical concerns. Adult stem cells (ASC) and reprogrammed cells provide viable alternatives for research and regenerative medicine.

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Chemical Reversion of Conventional Human Pluripotent Stem Cells to a Naïve-like State with Improved Multilineage Differentiation Potency
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Chemical Reversion of Conventional Human Pluripotent Stem Cells to a Naïve-like State with Improved Multilineage Differentiation Potency

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Scalable 96-well Plate Based iPSC Culture and Production Using a Robotic Liquid Handling System
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Scalable 96-well Plate Based iPSC Culture and Production Using a Robotic Liquid Handling System

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Last Updated: Jun 30, 2026

Reprogramming Primary Amniotic Fluid and Membrane Cells to Pluripotency in Xeno-free Conditions
09:34

Reprogramming Primary Amniotic Fluid and Membrane Cells to Pluripotency in Xeno-free Conditions

Published on: November 27, 2017

Chemical Reversion of Conventional Human Pluripotent Stem Cells to a Naïve-like State with Improved Multilineage Differentiation Potency
09:07

Chemical Reversion of Conventional Human Pluripotent Stem Cells to a Naïve-like State with Improved Multilineage Differentiation Potency

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Scalable 96-well Plate Based iPSC Culture and Production Using a Robotic Liquid Handling System
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Scalable 96-well Plate Based iPSC Culture and Production Using a Robotic Liquid Handling System

Published on: May 14, 2015

Area of Science:

  • Molecular Medicine
  • Stem Cell Biology
  • Bioethics

Background:

  • Embryonic stem cells (ESC) possess self-renewal and differentiation capabilities, making them valuable for molecular medicine.
  • ESC present significant challenges, including heightened tumorigenesis risk and ethical dilemmas associated with human ESC (hESC) derivation.
  • Adult stem cells (ASC) and induced pluripotent stem cells (iPSCs) offer alternative sources for stem cell applications.

Purpose of the Study:

  • To review the potential applications of ESC in research, therapy, and drug development.
  • To discuss the ethical considerations surrounding the use of ESC, particularly hESC.
  • To explore alternatives to ESC, such as ASC and iPSCs.

Main Methods:

  • Review of existing literature on stem cell biology and applications.
  • Analysis of ethical arguments concerning ESC use.
  • Consideration of scientific testimony regarding stem cell research.

Main Results:

  • ESC hold promise for regenerative medicine but pose risks like tumorigenesis.
  • Ethical issues surrounding hESC limit their clinical use.
  • Reprogramming techniques and ASC provide promising alternatives.

Conclusions:

  • The use of stem cells in medicine requires careful consideration of both therapeutic potential and ethical implications.
  • Alternative stem cell sources like ASC and iPSCs are crucial for advancing regenerative medicine.
  • Balancing scientific progress with ethical standards is paramount in stem cell research and application.