Prediction of solute sorption by polyvinyl chloride plastic infusion bags

The time course of the sorption of drugs by polyvinylchloride infusion bags has been approximated using a diffusion model in which the plastic is assumed to act as an infinite sink. This model appears to be suitable for estimation of storage times relevant to clinical usage and enables the magnitude of the uptake in a specific time to be described by a single parameter, referred to as the sorption number. This parameter is defined by the plastic-infusion solution partition coefficient, the diffusion coefficient in the plastic, the fraction un-ionized in solution, the volume of the infusion solution, and the surface area of the plastic. An approximation of the model allows a ready estimation of the sorption number from the fraction remaining in solution at a given time. The sorption number can be extrapolated to allow prediction of the effects of time, plastic surface area, solution volume, and solution pH on fractional solute loss. A reasonable correlation was established between the logarithm of this parameter and the logarithm of the octanol-water partition coefficients of various solutes. The model allows the fraction of a solute remaining in a plastic infusion bag at a given storage time to be estimated from the octanol-water partition coefficient of the solute and other readily available data.