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Related Experiment Video

Updated: Jun 30, 2026

Quantification of Global Diastolic Function by Kinematic Modeling-based Analysis of Transmitral Flow via the Parametrized Diastolic Filling Formalism

Quantification of Global Diastolic Function by Kinematic Modeling-based Analysis of Transmitral Flow via the Parametrized Diastolic Filling Formalism

Published on: September 1, 2014

Left ventricular diastolic function in normotensive type-2 diabetic subjects.

Dike Ojji¹, Will Parsonage, Mark Dooris

¹Division of Cardiovascular Medicine, Department of Medicine, University College Hospital, Ibadan, Nigeria. dikeojji@yahoo.co.uk

Journal of the National Medical Association

|September 24, 2008

Summary

Type-2 diabetes impairs left ventricular diastolic function in Nigerian adults, even without hypertension or obesity. This diastolic dysfunction affects African diabetic populations, similar to other ethnic groups.

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Area of Science:

Cardiology
Endocrinology
Diabetology

Background:

Previous studies on diabetic diastolic function often include confounding factors like hypertension and obesity.
Studying type-2 diabetes in developing nations offers a unique perspective with fewer confounding variables.
Assessing left ventricular diastolic function in Nigerian type-2 diabetics is crucial.

Purpose of the Study:

To evaluate the impact of type-2 diabetes mellitus on left ventricular diastolic function.
To investigate diastolic function in normotensive Nigerian subjects with type-2 diabetes.
To determine if diastolic dysfunction in diabetics is independent of obesity and hypertension.

Main Methods:

122 type-2 diabetic patients (age 35-74) and 91 healthy controls (age 40-75) were studied.
Exclusion criteria included hypertension (BP ≥140/90 mmHg) or antihypertensive treatment.
Transthoracic echocardiography assessed left ventricular diastolic filling patterns via mitral and pulmonary flow velocities.

Main Results:

58% of diabetic subjects showed impaired relaxation, 7% had pseudonormal filling, and 6% had restrictive filling.
Only 29% of diabetics had normal left ventricular filling compared to 58% of controls.
A statistically significant difference (X2 = 19.4, p = 0.0002) was observed in filling patterns.

Conclusions:

Nigerian type-2 diabetics exhibit impaired left ventricular filling compared to healthy individuals.
Diastolic dysfunction in this cohort is independent of confounding factors like obesity and elevated blood pressure.
African diabetic subjects, like other ethnic groups, are susceptible to diabetic diastolic dysfunction.