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Related Concept Videos

Bioreactor Design and Operational System01:29

Bioreactor Design and Operational System

Bioreactors are engineered vessels designed to cultivate microorganisms under controlled conditions for industrial bioprocessing. They maintain sterility and allow precise regulation of pH, temperature, oxygen, and nutrient levels to optimize microbial growth and metabolite production. Bioreactors range from small laboratory units of 1 liter to industrial systems holding up to 500,000 liters, though only about 75% of their volume is actively used for fermentation. The remaining headspace...
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Strain improvement is a foundational strategy in industrial microbiology aimed at maximizing microbial productivity, particularly because natural isolates typically yield commercially valuable products in very low concentrations. Although optimizing the culture medium and environmental conditions can improve yields, these adjustments are inherently limited by the organism’s genetic potential. As a result, the focus shifts toward genetic modifications to enhance biosynthetic capacity. The...
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Bioreactor Controls-I

Maintaining optimal conditions within fermenters is essential for maximizing microbial productivity and ensuring process efficiency. This lesson focuses on key parameters—temperature, foam, pH, carbon dioxide, oxygen, and pressure—and their precise measurement and control strategies in fermentation systems.Temperature ControlTemperature regulation is critical due to the exothermic nature of many fermentation processes. In small laboratory fermenters, temperature is commonly monitored using...
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Synthetic biology is an interdisciplinary science that involves using principles from disciplines such as engineering, molecular biology, cell biology, and systems biology. It involves remodeling existing organisms from nature or constructing completely new synthetic organisms for applications such as protein or enzyme production, bioremediation, value-added macromolecule production, and the addition of desirable traits to crops, to name a few.
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Upstream processing represents a critical phase in biomanufacturing, wherein biological systems such as microorganisms, mammalian cells, or insect cells are cultivated to produce therapeutic proteins, vaccines, enzymes, or other biologically derived products. This phase encompasses all steps from the selection and genetic manipulation of the production organism to the cultivation of cells in bioreactors under tightly controlled environmental conditions.Host Selection and Genetic OptimizationThe...
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The scale-up of microbial fermentation processes is essential in industrial biotechnology, allowing the transition from laboratory-scale experiments to commercial-scale production while aiming to maintain product yield and quality. This process requires meticulous adjustment of equipment design, process parameters, and contamination control strategies to accommodate increasing culture volumes.At the laboratory scale, cultures are typically maintained in 1 to 10-liter glass or autoclavable...

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Related Experiment Video

Updated: Jun 30, 2026

Operation of a Benchtop Bioreactor
12:54

Operation of a Benchtop Bioreactor

Published on: September 12, 2013

Industrial biosystems engineering and biorefinery systems.

Shulin Chen1

  • 1Institute ofMicrobiology, Chinese Academy ofSciences, Beijing 100101, China. chens@wsu.edu

Sheng Wu Gong Cheng Xue Bao = Chinese Journal of Biotechnology
|September 24, 2008
PubMed
Summary

Industrial Biosystems Engineering (IBsE) is a new field integrating systems biology, bioprocessing, and systems engineering to meet bioeconomy demands. This paper outlines its definition, framework, and future potential.

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Area of Science:

  • Industrial Biosystems Engineering (IBsE) represents a novel engineering discipline at the intersection of biological sciences and engineering principles.

Background:

  • The burgeoning bioeconomy necessitates specialized scientific, technological, and professional expertise.
  • Existing engineering fields require integration to address complex biological systems effectively.

Purpose of the Study:

  • To introduce and define the emerging field of Industrial Biosystems Engineering (IBsE).
  • To explore the theoretical underpinnings, methodologies, and scope of IBsE.
  • To identify challenges and future directions for this new discipline.

Main Methods:

  • Conceptualization and definition of Industrial Biosystems Engineering (IBsE).
  • Integration of principles from systems biology, bioprocessing, and systems engineering.
  • Discussion of theoretical frameworks and methodologies relevant to IBsE.

Main Results:

  • A foundational concept for Industrial Biosystems Engineering (IBsE) has been proposed.
  • The interdisciplinary nature of IBsE, bridging biology and engineering, is highlighted.
  • Key components including definition, framework, and methodologies are presented.

Conclusions:

  • Industrial Biosystems Engineering (IBsE) is positioned as a critical discipline for the future bioeconomy.
  • Further development and research are essential to realize the full potential of IBsE.
  • IBsE offers a systems-level approach to address complex challenges in biological and industrial applications.