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Updated: Jun 30, 2026
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Histological analysis of DuraGen in a human subject: case report
L Khorasani1, R P Kapur, C Lee
1Division of Pediatric Neurosurgery, Children's Hospital and Regional Medical Center, Seattle, WA, USA.
Object:
DuraGen (Integra Neurosciences, Plainsboro, NJ, USA) is an avascular collagen matrix used for dural closure. Although, numerous animal models have been studied, histological transformation of DuraGen in humans has not been reported.
Material And Method:
We analyzed a sample of scarred DuraGen used in a craniectomy patient at time of delayed cranioplasty.
Conclusion:
Histological analysis revealed evidence for both fibroblast infiltration and neovascularization of the DuraGen.
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