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Updated: Jun 30, 2026

Murine Intrapulmonary Tracheal Transplantation: A Model for Investigating Obliterative Airway Disease After Lung Transplantation

Murine Intrapulmonary Tracheal Transplantation: A Model for Investigating Obliterative Airway Disease After Lung Transplantation

Published on: November 10, 2023

Intentional ABO-incompatible lung transplantation.

M Strüber¹, G Warnecke, C Hafer

¹Division of Thoracic and Cardiovascular Surgery, Hannover Medical School, Hannover, Germany. strueber.martin@mh-hannover.de

American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons

|September 24, 2008

Summary

This summary is machine-generated.

A cystic fibrosis patient received an ABO-incompatible lung transplant due to donor organ scarcity. The successful procedure utilized antibody depletion, allowing the patient

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Last Updated: Jun 30, 2026

Murine Intrapulmonary Tracheal Transplantation: A Model for Investigating Obliterative Airway Disease After Lung Transplantation

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Published on: November 10, 2023

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Lung Rapid Recovery Procurement Combined with Abdominal Normothermic Regional Perfusion in Controlled Donation after Circulatory Death

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Published on: August 15, 2022

Area of Science:

Immunology
Transplantation Surgery
Pulmonology

Background:

Severe respiratory decompensation in cystic fibrosis necessitates lung transplantation.
Blood group O donor lung scarcity posed a challenge for a blood group O patient.
Mechanical ventilation and interventional lung assist were employed pre-transplant.

Observation:

An intentional ABO-incompatible lung transplant was performed.
A blood group AB donor lung was used for a blood group O recipient.
A comprehensive antibody depletion protocol was implemented.

Findings:

The protocol included plasmapheresis, intravenous immunoglobulin (ivIg), rituximab, and immunoadsorption.
The patient received pre-, peri-, and postoperative treatment.
The transplant was technically successful.

Implications:

ABO-incompatible lung transplantation is a viable option in urgent situations.
Aggressive immunosuppression can mitigate rejection in ABO-incompatible transplants.
This approach expands donor organ availability for critically ill patients.