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Phases of Wound Repair

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Following injury, the integrity of the injured tissues must be reestablished. For example, in skin tissue, wound repair involves coordination among resident skin cells, blood mononuclear cells, extracellular matrix, growth factors, and cytokines to complete the healing cascade.
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Updated: Jun 30, 2026

Assessment of Acute Wound Healing using the Dorsal Subcutaneous Polyvinyl Alcohol Sponge Implantation and Excisional Tail Skin Wound Models.

Assessment of Acute Wound Healing using the Dorsal Subcutaneous Polyvinyl Alcohol Sponge Implantation and Excisional Tail Skin Wound Models.

Published on: March 25, 2020

Microgravity and the implications for wound healing.

Ramin Mostofizadeh Farahani¹, Luisa A DiPietro

¹Department of Oral Biology, School of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran. r.mostofi@gmail.com

International Wound Journal

|September 24, 2008

Summary

This summary is machine-generated.

Microgravity appears to impair wound healing by affecting platelet function, growth factor production, and inflammatory cell activity. This review suggests spaceflight conditions may hinder the body's natural healing processes.

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Murine Excisional Wound Healing Model and Histological Morphometric Wound Analysis

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Published on: August 21, 2020

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Last Updated: Jun 30, 2026

Assessment of Acute Wound Healing using the Dorsal Subcutaneous Polyvinyl Alcohol Sponge Implantation and Excisional Tail Skin Wound Models.

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Published on: March 25, 2020

Murine Excisional Wound Healing Model and Histological Morphometric Wound Analysis

Murine Excisional Wound Healing Model and Histological Morphometric Wound Analysis

Published on: August 21, 2020

Area of Science:

Space medicine
Physiology
Regenerative medicine

Background:

Wound healing is a complex biological process essential for tissue repair after injury.
Understanding how environmental factors like microgravity affect healing is crucial for space exploration and astronaut health.

Purpose of the Study:

To review existing evidence on the impact of microgravity on the dynamics of wound healing.
To identify specific mechanisms by which microgravity may alter the healing cascade.

Main Methods:

Literature review of studies investigating microgravity effects on cellular and molecular aspects of wound repair.
Analysis of data concerning platelet function, growth factor release, inflammatory cell behavior, and cell proliferation under simulated or actual microgravity conditions.

Main Results:

Microgravity may alter the hemostatic phase by affecting platelet quantity and function.
The production of crucial growth factors (e.g., TGF-β, PDGF, EGF) and the infiltration/function of inflammatory cells appear to be impaired.
Gravity-dependent alterations in gap junctions, neural inputs, and cell populations are also reported.

Conclusions:

Microgravity significantly modifies cellular and extracellular components involved in wound healing.
These modifications suggest a potential impairment of wound healing dynamics in microgravity environments.
Further research is needed to fully elucidate the mechanisms and develop countermeasures for space missions.