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Related Experiment Video

Updated: Jun 30, 2026

Adapted Resistance Training Improves Strength in Eight Weeks in Individuals with Multiple Sclerosis

Adapted Resistance Training Improves Strength in Eight Weeks in Individuals with Multiple Sclerosis

Published on: January 29, 2016

The trials and errors in MS therapy.

Christoph Kleinschnitz¹, Sven G Meuth, Heinz Wiendl

¹Department of Neurology, University of Wurzburg, Wurzburg, Germany.

International MS Journal

|September 24, 2008

Summary

This summary is machine-generated.

Numerous multiple sclerosis (MS) therapies have been approved, but many novel drug trials since 2002 failed due to efficacy issues or adverse events. This review examines these challenges and their impact on MS treatment strategies.

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Published on: December 28, 2010

Area of Science:

Neurology
Immunology
Clinical Pharmacology

Background:

The development of novel therapies for multiple sclerosis (MS) has yielded several approved drugs in the last decade.
However, many therapeutic candidates have faced challenges, including trial failures due to lack of efficacy or safety concerns.

Purpose of the Study:

To review significant clinical trials of unlicensed compounds for relapsing-remitting and secondary-progressive MS since 2002.
To analyze trials that failed, were halted, or showed significant adverse effects.
To discuss the implications of these findings for understanding MS pathogenesis and designing future studies.

Main Methods:

Focus on clinical trials of novel compounds in relapsing-remitting and secondary-progressive MS.
Analysis of trials halted due to efficacy or adverse events.
Review of agents targeting leukocyte differentiation, co-stimulatory, and adhesion molecules, as well as immunomodulators and anti-infectives.

Main Results:

Several novel MS therapies have failed to demonstrate efficacy or were discontinued due to adverse events.
Highly immunoselective approaches, like monoclonal antibodies, carry risks of adverse effects.
Controversies exist regarding the practicality and clinical benefit of certain treatment strategies.

Conclusions:

Past trial failures provide critical insights into MS pathogenesis.
Experiences with failed therapies inform the design of future clinical trials for MS.
Careful consideration of efficacy, safety, and practicality is essential for advancing MS therapeutics.