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Related Concept Videos

Analgesia and Pain Management01:25

Analgesia and Pain Management

Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
Nociception01:44

Nociception

Nociception—the ability to feel pain—is essential for an organism’s survival and overall well-being. Noxious stimuli such as piercing pain from a sharp object, heat from an open flame, or contact with corrosive chemicals are first detected by sensory receptors, called nociceptors, located on nerve endings. Nociceptors express ion channels that convert noxious stimuli into electrical signals. When these signals reach the brain via sensory neurons, they are perceived as pain. Thus, pain helps the...
Pain01:20

Pain

Pain serves as a critical warning signal that alerts the body to potential or actual harm. When mechanical pressure on the skin is intense, such as from a sharp pinch, the sensation transitions from touch to pain. Similarly, extreme temperatures, like a hot pot handle, convert the sensation of heat into pain. Pain can also result from overstimulation of other senses, such as blinding light, loud noise, or the intense heat from habañero peppers. This ability to sense pain is essential for...
Local Anesthetics: Differential Sensitivity of Nerve Fibers01:24

Local Anesthetics: Differential Sensitivity of Nerve Fibers

Local anesthetics (LAs) block the sodium channels of nerve trunks, sensory nerve endings, and neuromuscular junctions. Although LAs can block all kinds of nerves, the sensitivity of nerve fibers differs according to nerve types and structures. LAs are known to block myelinated fibers faster than unmyelinated ones. Also, they block pain or sensory neurons at low concentrations without affecting the motor neurons involved in muscle contractions. This helps relieve labor pain without affecting the...

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Related Experiment Video

Updated: Jun 30, 2026

Chronic Constriction of the Sciatic Nerve and Pain Hypersensitivity Testing in Rats
08:23

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Published on: March 13, 2012

[Congenital insensitivity to pain].

N Danziger1, J-C Willer

  • 1Fédération de neurophysiologie clinique, faculté de médecine Pitié-Salpêtrière, groupe hospitalier Pitié-Salpêtrière, 91, boulevard de l'Hôpital, 75013 Paris, France. nicolas.danziger@psl.aphp.fr

Revue Neurologique
|September 24, 2008
PubMed
Summary

Congenital insensitivity to pain (CIP) is a rare genetic disorder impairing pain perception from birth. Recent discoveries link CIP to Nav1.7 sodium channel mutations, offering new insights into pain mechanisms.

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Related Experiment Videos

Last Updated: Jun 30, 2026

Chronic Constriction of the Sciatic Nerve and Pain Hypersensitivity Testing in Rats
08:23

Chronic Constriction of the Sciatic Nerve and Pain Hypersensitivity Testing in Rats

Published on: March 13, 2012

A Preterm Rat Model for Pain Studies
01:37

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Published on: February 9, 2024

Electrophysiological Measurement of Noxious-evoked Brain Activity in Neonates Using a Flat-tip Probe Coupled to Electroencephalography
06:29

Electrophysiological Measurement of Noxious-evoked Brain Activity in Neonates Using a Flat-tip Probe Coupled to Electroencephalography

Published on: November 29, 2017

Area of Science:

  • Neuroscience
  • Genetics
  • Pain Research

Context:

  • Congenital insensitivity to pain (CIP) is a rare condition affecting pain perception.
  • Historically linked to hereditary sensory and autonomic neuropathies (HSAN) impacting small nerve fibers.
  • Recent research identifies genetic mutations as a cause.

Purpose:

  • To explore the genetic underpinnings of Congenital Insensitivity to Pain (CIP).
  • To understand the role of the Nav1.7 sodium channel in nociception.
  • To investigate potential therapeutic targets for chronic pain.

Summary:

  • CIP is characterized by impaired pain perception from birth, often linked to HSAN affecting A-delta and C nerve fibers.
  • Genetic identification, particularly mutations in the Nav1.7 sodium channel gene, explains CIP in patients with normal nerve biopsies.
  • This contrasts with "gain of function" mutations causing pain syndromes, highlighting Nav1.7's dual role.

Impact:

  • Identifies Nav1.7 sodium channel mutations as a cause of CIP.
  • Suggests Nav1.7 and other nociception-related proteins as potential chronic pain therapeutic targets.
  • Offers insights into the neuropsychological aspects of pain, body image, and empathy.