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[Laboratory and clinical studies of cefpirome in pediatric field]
T Nishimura1, K Tabuki, S Aoki
1Department of Pediatrics, Osaka Medical College.
Insights
Cefpirome (CPR) demonstrated favorable pharmacokinetics and efficacy in pediatric bacterial infections. This cephalosporin antibiotic showed good tolerability with minimal side effects in clinical studies.
Area of Science:
- Pharmacology
- Pediatric Infectious Diseases
- Antibiotic Therapy
Background:
- Bacterial infections pose a significant health risk in pediatric populations.
- Novel antimicrobial agents are crucial for combating resistant pathogens.
- Cefpirome (CPR) is a fourth-generation cephalosporin with broad-spectrum activity.
Observation:
- Laboratory and clinical studies were conducted on cefpirome (CPR).
- CPR was administered via 30-minute drip infusion at a single dose of 20 mg/kg to pediatric patients.
- Pharmacokinetic parameters including peak serum levels, half-life, and urinary excretion rates were measured.
Findings:
- Mean peak serum level of CPR was 65.7 ± 2.2 µg/ml, with a mean half-life of 1.49 ± 0.046 hours.
- Mean urinary excretion rate was 57.0 ± 25.8% within the first 8 hours post-infusion.
- CPR showed excellent (6 cases) to good (3 cases) clinical outcomes in 9 pediatric patients with bacterial infections, including pneumonia and urinary tract infections.
Implications:
- Cefpirome exhibits promising pharmacokinetic properties and therapeutic effectiveness in pediatric bacterial infections.
- The drug was generally well-tolerated, with only minor, transient side effects observed, suggesting a favorable safety profile for pediatric use.
Abstract:
We have carried out laboratory and clinical studies on cefpirome (CPR, HR 810). The results are summarized as follows. CPR was given by 30-minute drip infusion to 3 children at a single dose of 20 mg/kg. After the 30-minute drip infusion, the mean peak serum level of CPR was 65.7 +/- 2.2 micrograms/ml at the end of infusion, and the mean half-life was 1.49 +/- 0.046 hours. The mean urinary excretion rate of CPR was 57.0 +/- 25.8% in the first 8 hours after the 30-minute drip infusion of 20 mg/kg. Treatment with CPR was made in 9 cases of pediatric bacterial infections; 1 case each of tonsillitis, pharyngitis, and bronchopneumonia, 4 cases of pneumonia, 2 cases of urinary tract infection. Results obtained were excellent in 6 cases, good in 3 cases. No significant side effects due to the drug were observed except one case of elevated GOT and GPT, and 3 cases of eosinophilia.