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[Clinical studies on cefpirome in pediatrics]
T Sekiguchi1, Y Shiino, K Murakawa
1Department of Pediatrics, Takamatsu Red Cross Hospital.
Insights
Cefpirome (CPR) effectively treated pediatric bacterial infections, including pneumonia and UTIs, in 10 children. All patients showed good clinical responses and bacterial eradication with minimal side effects.
Area of Science:
- Pediatric Infectious Diseases
- Clinical Pharmacology
- Bacteriology
Background:
- Bacterial infections pose significant health risks in children.
- Effective and safe antibiotic options are crucial for pediatric care.
- Cefpirome (CPR) is a cephalosporin antibiotic with broad-spectrum activity.
Purpose of the Study:
- To evaluate the clinical efficacy and safety of cefpirome (CPR) in pediatric patients with acute bacterial infections.
- To assess the impact of CPR on bacterial eradication in pediatric infections.
Main Methods:
- Intravenous administration of cefpirome (CPR) to 10 pediatric patients.
- Inclusion criteria: acute bacterial infections (pneumonia, pleuritis, urinary tract infections).
- Clinical response and bacterial eradication were monitored.
Main Results:
- Good to excellent clinical responses observed in all 10 patients.
- Bacterial eradication achieved in all 8 identified bacterial strains.
- Minor adverse events noted: transient elevation in GOT/GPT and eosinophilia in one patient each.
Conclusions:
- Cefpirome (CPR) demonstrates significant clinical utility and a favorable safety profile for treating pediatric bacterial infections.
- CPR is a valuable therapeutic option for acute bacterial infections in children, including pneumonia and UTIs.
Abstract:
Cefpirome (CPR, HR 810) was given intravenously to 10 children with acute bacterial infections including 8 with acute pneumonia, 1 each with acute pleuritis and urinary tract infections. Good to excellent clinical responses were obtained in all of the 10 patients and bacterial eradication were obtained for all 8 strains found in these cases. Slight elevation of GOT, GPT and eosinophilia were observed in 1 case each. From the above clinical results, it appears that CPR is a useful antibiotic for treatment of pediatric patients with various bacterial infections.