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[Clinical studies on cefpirome in pediatrics]
T Sekiguchi1, Y Shiino, K Murakawa
1Department of Pediatrics, Takamatsu Red Cross Hospital.
The Japanese Journal of Antibiotics
|April 1, 1991
Summary
Cefpirome (CPR) effectively treated pediatric bacterial infections, including pneumonia and UTIs, in 10 children. All patients showed good clinical responses and bacterial eradication with minimal side effects.
Area of Science:
- Pediatric Infectious Diseases
- Clinical Pharmacology
- Bacteriology
Background:
- Bacterial infections pose significant health risks in children.
- Effective and safe antibiotic options are crucial for pediatric care.
- Cefpirome (CPR) is a cephalosporin antibiotic with broad-spectrum activity.
Purpose of the Study:
- To evaluate the clinical efficacy and safety of cefpirome (CPR) in pediatric patients with acute bacterial infections.
- To assess the impact of CPR on bacterial eradication in pediatric infections.
Main Methods:
- Intravenous administration of cefpirome (CPR) to 10 pediatric patients.
- Inclusion criteria: acute bacterial infections (pneumonia, pleuritis, urinary tract infections).
- Clinical response and bacterial eradication were monitored.
Main Results:
- Good to excellent clinical responses observed in all 10 patients.
- Bacterial eradication achieved in all 8 identified bacterial strains.
- Minor adverse events noted: transient elevation in GOT/GPT and eosinophilia in one patient each.
Conclusions:
- Cefpirome (CPR) demonstrates significant clinical utility and a favorable safety profile for treating pediatric bacterial infections.
- CPR is a valuable therapeutic option for acute bacterial infections in children, including pneumonia and UTIs.