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Related Experiment Video

Updated: Jun 30, 2026

Dissecting the Non-human Primate Brain in Stereotaxic Space
09:09

Dissecting the Non-human Primate Brain in Stereotaxic Space

Published on: July 16, 2009

Striatal volume differences between non-human and human primates.

Dali Yin1, Francisco E Valles, Massimo S Fiandaca

  • 1Department of Neurosurgery, University of California San Francisco, 1855 Folsom Street, San Francisco, CA 94103, United States.

Journal of Neuroscience Methods
|September 24, 2008
PubMed
Summary

Accurately measuring brain structure volumes in non-human primates (NHP) is crucial for Parkinson's disease (PD) gene therapy. Human striatum and putamen are proportionally smaller than the whole brain compared to NHP, impacting treatment volume predictions.

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Area of Science:

  • Neuroscience
  • Neurosurgery
  • Gene Therapy

Background:

  • Convection-enhanced delivery (CED) is a promising gene therapy for Parkinson's disease (PD).
  • Accurate volume estimation is critical for stereotactic delivery of therapeutics into targets like the human putamen.
  • Preclinical non-human primate (NHP) studies are vital for modeling human therapies, but volumetric differences must be understood.

Purpose of the Study:

  • To compare striatal and whole brain volumes between humans and NHP.
  • To inform the design of CED-based gene therapies for neurological disorders by understanding species-specific volumetric ratios.

Main Methods:

  • Magnetic resonance imaging (MRI) was used for volumetric measurements.
  • Analyzed volumes of striatum (putamen, caudate nucleus) and whole brain in human subjects (PD patients, healthy controls) and NHP (normal, parkinsonian).

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A Comparative Approach for Quantitative Cell Counting Studies in Widely Different Mammalian Brains
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Related Experiment Videos

Last Updated: Jun 30, 2026

Dissecting the Non-human Primate Brain in Stereotaxic Space
09:09

Dissecting the Non-human Primate Brain in Stereotaxic Space

Published on: July 16, 2009

Large Volume, Behaviorally-relevant Illumination for Optogenetics in Non-human Primates
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Large Volume, Behaviorally-relevant Illumination for Optogenetics in Non-human Primates

Published on: October 3, 2017

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Published on: January 16, 2026

Main Results:

  • Human brains are 13-18 times larger than NHP brains.
  • The human striatum, caudate nucleus, and putamen are proportionally smaller than the whole brain compared to NHP, with ratios ranging from 4.4-6.6.

Conclusions:

  • Volumetric differences between human and NHP brains, particularly in the striatum, are significant.
  • These ratios are critical for translating NHP research to human clinical trials for PD and Huntington's disease gene therapies.
  • Consideration of these volumetric disparities is essential for optimizing local therapies like gene transfer and cellular replacement.