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[An autopsy case of primary lung leiomyosarcoma]
1Department of Clinical Laboratory, Juntendo Urayasu Hospital, Juntendo University School of Medicine.
Rinsho Byori. the Japanese Journal of Clinical Pathology
|June 1, 1991
Summary
This autopsy case details a rare primary lung leiomyosarcoma in an elderly man. Immunohistochemistry confirmed smooth muscle markers, aiding diagnosis of this aggressive tumor.
Area of Science:
- Pulmonology
- Oncology
- Pathology
Background:
- Leiomyosarcoma is a rare malignant mesenchymal tumor that can arise in various organs.
- Primary lung leiomyosarcoma is exceptionally rare, often presenting diagnostic challenges.
Observation:
- Autopsy of an 86-year-old male revealed a large (6x7x7 cm) primary leiomyosarcoma in the right lung.
- The tumor exhibited hemorrhage and necrosis, with additional smaller nodules in the lungs.
- Metastatic spread was observed in the heart, pericardium, liver, spleen, adrenal gland, and thyroid.
Findings:
- Microscopic examination showed 14 mitoses per 10 high-power fields, indicating high-grade malignancy.
- Immunohistochemical analysis was positive for smooth muscle myosin and actin.
- The tumor was negative for Carcinoembryonic Antigen (CEA).
Implications:
- This case highlights the importance of immunohistochemistry in diagnosing primary lung leiomyosarcoma.
- Findings contribute to understanding the histogenesis and differential diagnosis of rare lung tumors.
- The study underscores the aggressive nature and metastatic potential of pulmonary leiomyosarcoma.