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Related Concept Videos

Stem Cell Culture01:17

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
Renewal of Skin Epidermal Stem Cells01:12

Renewal of Skin Epidermal Stem Cells

The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular cells,...
Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own EpiSCs...
Multipotency and Niche of Bulge Stem Cell01:06

Multipotency and Niche of Bulge Stem Cell

A hair follicle or HF is a small part of the skin that produces the hair shaft. Paul Gerson Unna was the first to observe a bulge in the human hair follicle's outer root sheath (ORS). The bulge is present between the sebaceous gland and the arrector pili muscle and is the niche for hair follicle stem cells (HFSCs). The bulge is also a niche for melanocyte stem cells, and their loss results in graying of hair. The HFSCs express Sox9 and Lhx2, which help them maintain stemness and prevent...
iPS Cell Differentiation01:22

iPS Cell Differentiation

The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
Tissue Renewal without Stem Cells01:23

Tissue Renewal without Stem Cells

After cellular or tissue damage, the resident stem cells present in the human body can locally repair and regenerate the damaged tissue or organ. However, even though some tissues do not have stem cells, they can repair and regenerate with the help of pre-existing cells. For example, beta cells of the pancreas and hepatocytes of the liver can divide to renew and regenerate the tissue. Here, both cell division and cell death are well regulated by homeostasis.
However, failure of such a system...

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Related Experiment Video

Updated: Jun 30, 2026

Isolation and Culture of Adult Epithelial Stem Cells from Human Skin
08:26

Isolation and Culture of Adult Epithelial Stem Cells from Human Skin

Published on: March 31, 2011

Human skin stem cells and the ageing process.

Christos C Zouboulis1, James Adjaye, Hirohiko Akamatsu

  • 1Department of Dermatology, Venereology, Allergology and Immunology, Dessau Medical Center, Dessau, Germany. christos.zouboulis@klinikum-dessau.de

Experimental Gerontology
|September 24, 2008
PubMed
Summary
This summary is machine-generated.

Skin stem cells maintain skin integrity and regeneration. Aging skin may result from impaired stem cell function, not reduced numbers, highlighting their importance in regenerative medicine and aging studies.

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Naïve Adult Stem Cells Isolation from Primary Human Fibroblast Cultures
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Naïve Adult Stem Cells Isolation from Primary Human Fibroblast Cultures

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Last Updated: Jun 30, 2026

Isolation and Culture of Adult Epithelial Stem Cells from Human Skin
08:26

Isolation and Culture of Adult Epithelial Stem Cells from Human Skin

Published on: March 31, 2011

Naïve Adult Stem Cells Isolation from Primary Human Fibroblast Cultures
07:39

Naïve Adult Stem Cells Isolation from Primary Human Fibroblast Cultures

Published on: May 3, 2013

Area of Science:

  • Dermatology and Regenerative Medicine
  • Stem Cell Biology
  • Aging Research

Background:

  • Skin integrity relies on epidermal stem cells for self-renewal and differentiation.
  • Despite senescence in aged skin, stem cell numbers remain stable, suggesting functional impairment.
  • Distinct stem cell populations exist in the skin, including hair follicle bulge and sebaceous gland progenitors.

Purpose of the Study:

  • To explore the role of various skin stem cell populations in maintaining skin integrity and regeneration.
  • To investigate the potential causes of skin aging related to stem cell function.
  • To highlight the therapeutic potential of skin stem cells in regenerative medicine.

Main Methods:

  • Genetic labeling studies to track stem cell populations and their regenerative capabilities.
  • Analysis of stem cell behavior in response to skin injury and aging.
  • Characterization of multipotent stem cells in human dermis and sebaceous glands.

Main Results:

  • Hair follicle bulge stem cells regenerate hair follicles and epidermis, showing multipotency.
  • Interfollicular epidermis is maintained by a distinct stem cell population.
  • Dermal stem cells and sebaceous gland progenitors contribute to skin regeneration and differentiation.

Conclusions:

  • Skin stem cells possess self-renewal and multi-lineage differentiation capabilities, crucial for tissue repair and regeneration.
  • Impaired stem cell mobilization or responsiveness, rather than reduced numbers, likely drives skin aging.
  • Skin stem cells offer significant potential for regenerative medicine, gene therapy, and in vitro aging models.