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Updated: Jun 30, 2026

Social Threat-Safety Test Uncovers Psychosocial Stress-Related Phenotypes
Published on: December 15, 2023
Psychobiological responses to social threat: evolution of a psychological model in psychoneuroimmunology
1Health Psychology Program, Department of Psychiatry, University of California San Francisco School of Medicine, 3333 California Street, Suite 465, San Francisco, CA 94143-0848, USA. kemenym@healthpsych.ucsf.edu
Abstract:
There exists a bidirectional network of interactions between the central nervous system, the endocrine system and the immune system. The existence of these pathways allows stressful life experience to impact the immune system with important implications for health. One powerful elicitor of changes in the autonomic, endocrine and immune systems is threat to social status. This review describes the development of a human model of social status threat that specifies a set of contextual, psychological and biological pathways that may underlie the health consequences of threats to social status and regard. The role of cognitive processes in shaping the physiological response to the social world will be emphasized.
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