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A High-throughput Platform for the Screening of Salmonella spp./Shigella spp.
06:55

A High-throughput Platform for the Screening of Salmonella spp./Shigella spp.

Published on: November 7, 2018

Rising prevalence of enteric fever due to multidrug-resistant Salmonella: an epidemiological study

Surinder Kumar1, Meher Rizvi1, Nidhika Berry1

  • 1Department of Microbiology, Maulana Azad Medical College, Bahadur Shah Zafar Marg, New Delhi, India.

Journal of Medical Microbiology
|September 24, 2008
PubMed

Insights

Enteric fever in North India is primarily caused by Salmonella Typhi and Paratyphi A. Antibiotic resistance, including to fluoroquinolones, is increasing, necessitating judicious antibiotic use.

Area of Science:

  • Medical Microbiology
  • Infectious Diseases
  • Antimicrobial Resistance

Background:

  • Enteric fever remains a significant public health concern, particularly in North India.
  • Understanding the etiological agents and their antimicrobial susceptibility patterns is crucial for effective treatment.

Purpose of the Study:

  • To investigate the prevalent causes of enteric fever over time in North India.
  • To monitor trends in antimicrobial resistance among Salmonella isolates.

Main Methods:

  • Prospective study conducted at a tertiary care hospital over several years.
  • Isolation and identification of Salmonella species from patient samples.
  • Antimicrobial susceptibility testing, including assessment of multidrug resistance and extended-spectrum beta-lactamase (ESBL) production.

Main Results:

  • Salmonella species were identified in 7% of patients, with Salmonella Typhi being the most common (80%), followed by Salmonella Paratyphi A (9%).
  • Multidrug resistance (to chloramphenicol, ampicillin, co-trimoxazole) increased from 34% to 66% between 1999 and 2005.
  • Emerging resistance to fluoroquinolones was observed, with resistance rates to ciprofloxacin reaching 13% in 2005.
  • 8% of Salmonella Typhi isolates were presumptive ESBL producers.

Conclusions:

  • Salmonella Typhi and Paratyphi A are the primary causes of enteric fever in the studied region.
  • There is a concerning rise in multidrug resistance and emerging resistance to fluoroquinolones and cephalosporins.
  • Judicious use of fluoroquinolones and third-generation cephalosporins is essential to preserve their efficacy against Salmonella infections.

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