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Related Concept Videos

Chemical Ionization (CI) Mass Spectrometry01:21

Chemical Ionization (CI) Mass Spectrometry

The molecular ion peak of a molecule in the mass spectrum provides vital information for molecular identification. However, conventional electron impact ionization can lead to the rapid dissociation of some molecular ions before they reach the detector. A milder ionization method is required to increase the lifetime of such ionized analyte molecules. Chemical ionization (CI) is a gas-phase protonation reaction useful for mass-analyzing analyte molecules that are easily protonated to yield the...
Mass Spectrometers01:16

Mass Spectrometers

This lesson details the instrumentation of a mass spectrometer—a physical instrument to perform mass spectrometry on analyte molecules and record the characteristic mass spectra. This is achieved via three chief functions:
Inductively Coupled Plasma–Mass Spectrometry (ICP–MS): Overview01:19

Inductively Coupled Plasma–Mass Spectrometry (ICP–MS): Overview

In inductively coupled plasma–mass spectrometry (ICP–MS), an inductively coupled plasma (ICP) torch is used as an atomizer and ionizer. Solid samples are dissolved and volatilized before being introduced into the high-temperature argon plasma, while solution samples are nebulized and passed through the high-temperature argon plasma. Plasma dissociates the analytes and ionizes their component atoms to form a mixture of positive ions and molecular species. The positive ions are then passed on to...
Mass Spectrometry: Overview01:19

Mass Spectrometry: Overview

Mass spectrometry is an analytical technique used to determine the molecular mass and molecular formula of a compound. The basic principle of mass spectrometry is to generate ions from the analyte molecule and measure these ion abundances against their molecular mass. One common type of ionization, known as electron ionization or EI, bombards the analyte molecules in the gas phase with high-energy electron beams. The electron beams displace an electron from the molecule and leave behind a...
Tandem Mass Spectrometry01:21

Tandem Mass Spectrometry

Tandem mass spectrometry is a technique that uses multiple mass analyzers in series to obtain a higher selectivity and reduce chemical noise during analyte detection. Instruments with multiple analyzers separated by an interaction cell enable secondary fragmentation and selected study of the fragment ions.Secondary fragmentations occur in the interaction cell and can be induced by various factors. Fragmentation induced by collision with inert gases, such as N2, Ar, He, etc., is called...
Mass Spectrometry: Complex Analysis01:21

Mass Spectrometry: Complex Analysis

Mass spectrometry is an important technique for the identification of pure compounds. However, it has some limitations for the analysis of complex mixtures, often due to excessive fragmentation making the spectrum too complicated to decipher. Mass spectrometry can be combined with suitable separation methods in sequence, forming hyphenated methods, which are useful in the analysis of complex mixtures.
GC–MS is a powerful hyphenated method commonly used in forensics and environmental...

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Visualization of Ambient Mass Spectrometry with the Use of Schlieren Photography
06:49

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Published on: June 20, 2016

Recent developments in ambient ionization techniques for analytical mass spectrometry.

Glenn A Harris1, Leonard Nyadong, Facundo M Fernandez

  • 1School of Chemistry & Biochemistry, Georgia Institute of Technology, 901 Atlantic Drive NW, Atlanta, GA 30332-0400, USA.

The Analyst
|September 24, 2008
PubMed
Summary

Ambient ionization mass spectrometry allows analyzing samples in their natural state. This review covers advancements in ionization techniques since 2004 for broad and high-throughput screening.

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Area of Science:

  • Analytical Chemistry
  • Mass Spectrometry
  • Chemical Analysis

Background:

  • Ambient ionization techniques permit mass spectrometry analysis of samples in their native state.
  • These methods are crucial for high-throughput and broad screening applications across various scientific fields.

Purpose of the Study:

  • To introduce the field of ambient ionization mass spectrometry.
  • To review different ionization approaches developed since 2004.
  • To highlight recent advancements in the field.

Main Methods:

  • Literature review of ambient ionization techniques.
  • Focus on developments and applications since 2004.
  • Emphasis on recent innovations and methodologies.

Main Results:

  • Ambient ionization mass spectrometry has rapidly advanced.
  • A diverse range of ionization approaches have been reported.
  • Recent developments focus on enhanced sensitivity and broader applicability.

Conclusions:

  • Ambient ionization is a rapidly evolving field with significant potential.
  • These techniques are increasingly valuable for diverse analytical challenges.
  • Continued innovation promises further expansion of their applications.