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Related Concept Videos

Microbial Biosensors01:17

Microbial Biosensors

Microbial biosensors are analytical devices that utilize living microbes to detect specific substances through measurable signals. These devices consist of two main components: biosensing organisms and signal-transducing elements. Biosensing organisms, such as Escherichia coli or Saccharomyces cerevisiae, are typically housed in multiwell plates connected to transducers, enabling rapid, real-time detection of target analytes.Signal Generation MechanismWhen a target analyte—such as...

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Related Experiment Video

Updated: Jun 30, 2026

Sample Preparation for Probe Electrospray Ionization Mass Spectrometry
05:47

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Published on: February 19, 2020

[Miniprobe EUS].

H Seifert1, A Schütte

  • 1Klinik für Gastroenterologie, Hepatologie, Diabetologie und Infektionskrankheiten, Klinikum Oldenburg, Rahel-Straus-Str. 10, 26133 Oldenburg. seifert.hans@klinikumoldenburg.de

Zeitschrift Fur Gastroenterologie
|September 24, 2008
PubMed
Summary
This summary is machine-generated.

Endoscopic ultrasound (EUS) miniprobes enhance routine endoscopy by providing detailed imaging of intestinal walls and surrounding organs. This powerful tool aids in diagnosing conditions like bile duct stones and staging early cancers.

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Area of Science:

  • Gastroenterology
  • Medical Imaging
  • Endoscopy

Background:

  • Flexible, high-frequency catheter probes (miniprobes) integrate with endoscopes.
  • Endoscopic ultrasound (EUS) offers detailed imaging up to 20mm depth with 20 MHz frequencies.
  • Miniprobes visualize intestinal wall structures and surrounding organs.

Purpose of the Study:

  • To evaluate the diagnostic utility of miniprobe EUS in various gastrointestinal conditions.
  • To assess the effectiveness of miniprobe EUS in evaluating distal bile ducts and staging early cancers.

Main Methods:

  • 1007 miniprobe EUS examinations were conducted.
  • Water filling of the intestinal lumen optimized sonographic coupling.
  • Extraductal EUS (EDUS) was used for evaluating distal common bile duct lesions.

Main Results:

  • Frequent indications included distal bile/pancreatic ducts (36%), esophageal/cardia carcinoma (18%), and submucosal tumors/GIST (14%).
  • EDUS achieved 97% sensitivity and 98% specificity for detecting small intraductal stones without ductal dilatation.
  • Miniprobe EUS accurately identified lesion layers and excluded non-resectable T2 cancer by visualizing a preserved submucosal layer.

Conclusions:

  • Miniprobe EUS is a valuable diagnostic tool supplementing routine endoscopy.
  • It demonstrates high accuracy in diagnosing bile duct stones and staging early esophageal cancers.
  • The technology aids in differentiating intraluminal lesions from external impressions and assessing tumor resectability.