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[Changes in coagulation hemostasis in patients after coronary bypass surgery]

I L Faĭl', V T Dolgikh, N A Morova

    Klinicheskaia Laboratornaia Diagnostika
    |September 24, 2008
    PubMed

    Insights

    Coronary bypass surgery patients show increased hypercoagulation and suppressed fibrinolysis post-operation. Extended anticoagulant therapy and hemostasiogram monitoring are crucial for managing these hemostatic changes.

    Area of Science:

    • Cardiovascular Surgery
    • Hemostasis and Thrombosis
    • Clinical Coagulation

    Context:

    • Investigates hemostatic changes in patients undergoing coronary artery bypass grafting (CABG).
    • Compares coagulation profiles before and after surgery in patients versus healthy controls.
    • Focuses on alterations in the coagulation system following CABG procedures.

    Purpose:

    • To analyze the impact of CABG on the coagulation link of hemostasis.
    • To identify specific hemostatic disorders present before and after surgery.
    • To evaluate the role of anticoagulant therapy and monitoring post-CABG.

    Summary:

    • Pre-operative ischemic heart disease patients exhibited hyperfibrinogenemia, suppressed fibrinolysis, thrombinemia, and elevated D-dimer.
    • Post-CABG, patients showed significantly increased hypercoagulation and further fibrinolytic suppression.
    • A decrease in protein C system anticoagulants was observed post-surgery.

    Impact:

    • Highlights the necessity for prolonged anticoagulant use in the postoperative period.
    • Emphasizes the importance of continuous hemostasiogram monitoring after discontinuing anticoagulants.
    • Provides insights into managing thrombotic risks associated with CABG surgery.

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