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Related Concept Videos

Oxidation of Phenols to Quinones01:17

Oxidation of Phenols to Quinones

In the presence of oxidizing agents, phenols are oxidized to quinones. Quinones can be easily reduced back to phenols using mild reducing agents. The electron-donating hydroxyl group enhances the reactivity of the aromatic ring, enabling oxidation of the ring even in the absence of an α hydrogen.
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The oxidation of an organic compound in the presence of air or oxygen is called autoxidation. For example, cumene reacts with oxygen to form hydroperoxide. Autoxidation involves initiation, propagation, and termination steps. Many organic compounds are susceptible to autoxidation—especially ethers in the presence of oxygen, which form hydroperoxides. Even though this reaction is slow, old ether bottles contain small amounts of peroxide, which leads to laboratory explosions during ether...

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Non-phenolic antioxidant compounds from Buddleja asiatica.

Mortada M el-Sayed1, El-Sayed S Abdel-Hameed, Wafaa S Ahmed

  • 1Laboratory of Medicinal Chemistry, Theodor Bilharz Research Institute, Warrak El-Hader, Egypt.

Zeitschrift Fur Naturforschung. C, Journal of Biosciences
|September 25, 2008
PubMed
Summary

The methanol extract of Buddleja asiatica leaves exhibits significant antioxidant properties. Four novel compounds were isolated and identified, demonstrating potent free radical scavenging capabilities in vitro.

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Area of Science:

  • Phytochemistry
  • Pharmacology
  • Natural Products Chemistry

Background:

  • Buddleja asiatica Lour. is a plant species with a history of traditional medicinal use.
  • Oxidative stress is implicated in various chronic diseases, driving the search for natural antioxidants.
  • Understanding the chemical constituents and antioxidant potential of medicinal plants is crucial for drug discovery.

Purpose of the Study:

  • To investigate the antioxidant activity of Buddleja asiatica leaf extract.
  • To isolate and identify antioxidant compounds from the n-butanol fraction.
  • To evaluate the antioxidant capacity of the isolated compounds.

Main Methods:

  • In vitro antioxidant assays: phosphomolybdenum method, DPPH assay, and hydrogen peroxide scavenging.
  • Chromatographic separation techniques (column chromatography) for isolation of compounds.
  • Spectroscopic and chemical analyses for structural elucidation (NMR, MS).

Main Results:

  • The methanol extract demonstrated significant antioxidant activity in all tested assays.
  • The n-butanol fraction showed high scavenging activity against DPPH and H2O2 radicals (SC50 values provided).
  • Four non-phenolic compounds were successfully isolated and identified: compound 1 (a glycerol derivative), and compounds 2, 3, and 4 (oleanane triterpenoid saponins).

Conclusions:

  • Buddleja asiatica leaf extract possesses notable in vitro antioxidant properties.
  • The isolated compounds, particularly the triterpenoid saponins, are responsible for the observed antioxidant effects.
  • Further research into these compounds may lead to the development of new antioxidant agents.