Related Experiment Video

Updated: Jun 30, 2026

Intracerebroventricular and Intravascular Injection of Viral Particles and Fluorescent Microbeads into the Neonatal Brain
05:51

Intracerebroventricular and Intravascular Injection of Viral Particles and Fluorescent Microbeads into the Neonatal Brain

Published on: July 24, 2016

Leukoencephalopathy with anterior temporal cysts due to congenital CMV infection diagnosed retrospectively

Declan O'Rourke1, Lisa Bradley, Mary D King

  • 1Department of Pediatric Neurology, Children's University Hospital, Dublin 1, Ireland.

Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging
|September 25, 2008
PubMed

Insights

Congenital cytomegalovirus (CMV) infection can cause leukoencephalopathy with subcortical cysts. This rare cause was identified retrospectively in a 1-year-old girl with developmental delay and hearing loss.

Area of Science:

  • Neurology
  • Infectious Diseases
  • Pediatrics

Background:

  • Leukoencephalopathy with subcortical cysts is a rare neuroimaging finding.
  • Congenital cytomegalovirus (CMV) infection is a common congenital infection with potential neurological sequelae.
  • The association between congenital CMV and leukoencephalopathy with subcortical cysts is infrequently reported.

Observation:

  • A 1-year-old girl presented with developmental delay and sensorineural hearing loss.
  • Brain MRI revealed abnormal white matter and temporal lobe cysts.
  • The patient's history was reviewed for potential causes of these findings.

Findings:

  • Congenital CMV infection was diagnosed retrospectively in the patient.
  • Diagnosis was confirmed through examination of a dried blood spot from newborn screening.
  • This case highlights congenital CMV as a potential cause of leukoencephalopathy with subcortical cysts.

Implications:

  • This case underscores the importance of considering congenital CMV in the differential diagnosis of leukoencephalopathy with subcortical cysts.
  • Early diagnosis of congenital CMV is crucial for timely intervention and management of neurological complications.
  • Further research may elucidate the specific mechanisms by which CMV causes these neuroimaging abnormalities.

More Related Videos

Use of In vivo Imaging to Monitor the Progression of Experimental Mouse Cytomegalovirus Infection in Neonates05:53

Use of In vivo Imaging to Monitor the Progression of Experimental Mouse Cytomegalovirus Infection in Neonates

Published on: July 6, 2013

Frontal Disconnection for Treating Mild Malformation of Cortical Development with Oligodendroglial Hyperplasia in Epilepsy (MOGHE) in the Frontal Lobe06:04

Frontal Disconnection for Treating Mild Malformation of Cortical Development with Oligodendroglial Hyperplasia in Epilepsy (MOGHE) in the Frontal Lobe

Published on: August 16, 2024

Related Concept Videos

Cytomegalovirus Disease01:27

Cytomegalovirus Disease

Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...
Cryptococcal Meningitis01:27

Cryptococcal Meningitis

Cryptococcal meningitis is a life-threatening opportunistic infection predominantly associated with HIV/AIDS, accounting for over 100,000 deaths annually worldwide. However, it also affects individuals with other forms of immunosuppression, including those undergoing immunosuppressive therapy, organ transplant recipients, patients with innate immunodeficiencies, and individuals with hematological disorders. The infection is caused mainly by Cryptococcus neoformans and Cryptococcus gattii,...
Encephalitis l: Introduction01:19

Encephalitis l: Introduction

Encephalitis is inflammation of the brain parenchyma, most often due to infections or autoimmune processes. It presents with neuropsychiatric features such as fever, altered mental status, behavioral changes, cognitive dysfunction, seizures, focal deficits, and sometimes autonomic instability. In some cases, the meninges are also involved, resulting in meningoencephalitis.Infectious CausesInfectious encephalitis is most commonly viral but can also result from bacterial, fungal, or parasitic...
Brain Abscess l: Introduction01:26

Brain Abscess l: Introduction

A brain abscess is a focal, intracerebral infection characterized by a localized collection of pus within the brain parenchyma, resulting from microbial invasion and the body’s inflammatory response. It progresses through stages: early and late cerebritis, followed by early and late capsule formation, reflecting tissue destruction, immune response, and eventual encapsulation.Etiology and PathogenesisCausative organisms vary with source and host factors, often involving polymicrobial infections,...
Viral Meningitis01:18

Viral Meningitis

Viral meningitis is the most common form of meningitis and is often referred to as aseptic meningitis to indicate the absence of bacterial involvement. It is generally milder than bacterial meningitis, with symptoms including fever, headache, stiff neck, drowsiness, nausea, photophobia, and vomiting. Rarely, more severe manifestations or death may occur. Common causative agents include enteroviruses, particularly coxsackie A and B viruses and echoviruses, all members of the Enterovirus genus...
Encephalitis ll: Pathophysiology01:26

Encephalitis ll: Pathophysiology

Encephalitis is inflammation of the brain parenchyma caused by direct viral invasion or immune-mediated mechanisms triggered by infections or tumors. Both processes lead to neuronal injury, disrupted neurotransmission, and diverse neurological symptoms, often with overlapping clinical and pathological features.Autoimmune EncephalitisIn autoimmune encephalitis, antibodies target neuronal antigens on cell surfaces, synapses, or within neurons. A key example is anti-NMDAR encephalitis, which can...