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Updated: Jun 30, 2026
Depletion and Reconstitution of Macrophages in Mice
Published on: August 1, 2012
Inter-strain differences in glucocorticoid and mineralocorticoid effects on macrophage and lymphocyte functions in
H Harizi1, P Mormède, J-B Corcuff
1Laboratoire PsyNuGen, INRA UMR1286, CNRS UMR5226, Université de Bordeaux 2, France. harizihedi33@yahoo.fr
Abstract:
We showed previously and we confirm here that macrophages from three mouse strains are differentially sensitive to the inhibition of expression of key inflammatory proteins (iNOS-II, IL-1 beta) by dexamethasone, a specific glucocorticoid receptor agonist (C57BL/6>DBA/2>BALB/c). Here we show that aldosterone (a specific mineralocorticoid agonist) has no effect on iNOS-II or IL-1 beta expression in macrophages from these mouse strains but decreases IL-1ra expression, with small inter-strain differences. This mechanism may be involved in the pro-inflammatory effect of this hormone. Concanavalin A-stimulated lymphocytes proliferation is also differentially sensitive to dexamethasone according to the strain, but insensitive to aldosterone.
