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Synthesis of Thermogelling Poly(N-isopropylacrylamide)-graft-chondroitin Sulfate Composites with Alginate Microparticles for Tissue Engineering
Published on: October 26, 2016
Synthesis of potent water-soluble tissue transglutaminase inhibitors
Martin Griffin1, Alexandre Mongeot, Russell Collighan
1School of Life and Health Sciences, Aston University, Aston Triangle, Birmingham B4 7ET, UK. m.griffin@aston.ac.uk
Bioorganic & Medicinal Chemistry Letters
|September 25, 2008
Abstract:
Dipeptide-based sulfonium peptidylmethylketones derived from 6-diazo-5-oxo-L-norleucine (DON) have been investigated as potential water-soluble inhibitors of extracellular transglutaminase. The lead compounds were prepared in four steps and exhibited potent activity against tissue transglutaminase.
