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Stability tests for hematological parameters in antidoping analyses.

Sven Christian Voss1, Ulrich Flenker, Bettina Majer

  • 1Institute of Biochemistry, German Sports University Cologne, Cologne, Germany. s.voss@biochem.dshskoeln.de

Laboratory Hematology : Official Publication of the International Society for Laboratory Hematology
|September 25, 2008
PubMed
Summary
This summary is machine-generated.

Delayed analysis of blood samples for anti-doping tests shows erythrocyte and reticulocyte parameters remain stable for 48 hours when stored at 4°C. Chilled storage is recommended for accurate individual blood profiling.

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Area of Science:

  • Clinical chemistry
  • Hematology
  • Sports science

Background:

  • Accurate athlete monitoring relies on stable blood parameters.
  • Delayed sample analysis can impact test results in anti-doping.
  • Erythrocyte and reticulocyte parameters are crucial for detecting doping agents.

Purpose of the Study:

  • To assess the stability of erythrocyte and reticulocyte parameters for anti-doping tests.
  • To evaluate the impact of delayed analysis and storage temperature on these parameters.
  • To determine optimal storage and analysis timelines for reliable anti-doping results.

Main Methods:

  • Blood samples were analyzed on the ADVIA120 system.
  • Key erythrocyte and reticulocyte parameters were measured over 48 hours.
  • Samples were stored at either 4°C or 21°C.
  • Linear and nonlinear mixed-effects models were used for data analysis.

Main Results:

  • Storage at 4°C was superior to room temperature (21°C).
  • Erythrocyte count, hemoglobin, and several reticulocyte parameters showed sufficient stability for 48 hours at 4°C.
  • Parameters like hematocrit and mean cell volume exhibited less stability.
  • OFF-Score and percentage of high-fluorescent reticulocytes remained stable.

Conclusions:

  • Storing samples at 4°C is recommended for maintaining the integrity of erythrocyte and reticulocyte parameters.
  • Analysis should be conducted within 48 hours of sample collection for reliable anti-doping testing.
  • These findings support the establishment of accurate individual blood profiles for athletes.